Die Chorioallantoismembran des befruchteten Hühnereis als in vivo-Ersatzsystem für die Photodynamische Therapie View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1997

AUTHORS

K. Kunzi-Rapp , C. Westphal-Frösch , N. Akgün , A. Rück , H. Schneckenburger , R. Steiner

ABSTRACT

Die Chorioallantoismembran (CAM) des befruchteten Hühnereis bietet ein ausgezeichnetes Substrat für Tumorzellen sowie für die Transplantation von Fremdgewebe. Außerdem erlauben die Gefäße der CAM eine direkte Beobachtung der Mikrozirkulation. Dies sind ideale Voraus¬setzungen zur Untersuchung der Mechanismen der Photodynamischen Therapie sowohl im Tumor als auch simultan an tumorversorgenden Gefäßen. Die Lokalisation eines Sensibilisators ist anhand seiner Fluoreszenz im CAM-Modellsystem relativ einfach zu beobachten. Dieser Parameter wurde benutzt, um Aufnahme, Verteilung und Speicherung verschiedener natürlicher Porphyrine und des synthetischen Porphyrinderivates Photosan 3 in Echtzeit zu detektieren. Parallel dazu wurden Änderungen der Morphologie mit Hilfe der Lichtmikroskopie beobachtet. Analog zu den bisher üblichen Versuchen an tumortragenden Mäusen wurde ein Blasenkarzinomstück auf die CAM transplantiert. Nach Photodynamischer Therapie mit Photosan 3 konnte eine makroskopisch sichtbare Reduktion des Tumors beobachtet werden. The chorioallantoic membrane of the fertilized hen’s egg as an in vivo system for photodynamic therapy The chorioallantoic membrane of the fertilized hen’s egg serves as an excellent host for tumor cells and grafts. In addition the vessels of the chorioallantoic membran permit a direct obser-vation of the microcirculation. This conditions are ideal for studying the mechanisms of photo-dynamic therapy in tumors as well as in tumor vessels. The localization of a sensitizer due to its fluorescence can be easily detected in the chorio-allantoic membrane system. This parameter was used to detect uptake, distribution and storage of natural and synthetic porphyrins in real-time. Similar to the common experiments with tumor bearing mice we transplanted a human bladder tumor to the chorioallantoic membrane. 48 hours after photodynamic therapy with Photosan 3 we detected an obvious reduction of the tumor while a control placed on the same egg was growing further. More... »

PAGES

154-158

Book

TITLE

Forschung ohne Tierversuche 1996

ISBN

978-3-211-82869-4
978-3-7091-6833-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-7091-6833-2_21

DOI

http://dx.doi.org/10.1007/978-3-7091-6833-2_21

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029292483


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