Synthesis and Biological Activity of a Series of Methylene-Expanded Oxetanocin Nucleoside Analogues View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2002

AUTHORS

Michael E. Jung , Akemi Toyota , Erik de Clercq , Jan Balzarini

ABSTRACT

A series of methylene-expanded oxetanocin nucleoside analogues, e.g. analogues of 2 and the known antiviral nucleosides AZT, FLT, and ddC (3) were prepared by a very direct route beginning with the readily available (S)-glycidol 4 and proceeding via the dihydrofuran-3-methanols 9a,b. Biological testing of these modified nucleosides indicates that they are non-cytotoxic compounds with generally weak antiviral activity. However, the guanosine analogue 2G showed pronounced activity vs. herpes simplex virus type 1 (HSV-1) in cell culture and was HSV-1-encoded thymidine kinase dependent. This compound is therefore an interesting new lead structure for the development of new anti-HSV agents. More... »

PAGES

149-170

Book

TITLE

Timely Research Perspectives in Carbohydrate Chemistry

ISBN

978-3-7091-7289-6
978-3-7091-6130-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-7091-6130-2_10

DOI

http://dx.doi.org/10.1007/978-3-7091-6130-2_10

DIMENSIONS

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