Brain changes in iron loading disorders View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Elizabeth Milward , Bulent Acikyol , Brianna Bassett , Evan Williams , Ross Graham , Roheeth Delima , Deborah Trinder , John Olynyk , Daniel Johnstone

ABSTRACT

Abnormal iron accumulation within the brain is associated with various neurodegenerative diseases; however, there is debate about whether milder disorders of systemic iron loading, such as haemochromatosis, affect the brain. Arguments on both sides of the debate are often based on some common assumptions that have not been rigorously tested by appropriate experimentation. Recent research from our lab has applied high-throughput molecular techniques such as microarray to models of dietary and genetic iron loading to identify subtle but important effects on molecular systems in the brain that may go undetected by other methods commonly used in the field. In this chapter, we review the existing research in animal models and human patients and discuss the strengths and limitations of the different approaches commonly used. Using our findings as an example, we argue that transcriptomic methods can provide unique insights into how systemic iron loading can affect the brain and suggest some basic guidelines for extracting the most robust and reliable information from microarray studies. More... »

PAGES

17-29

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  • Book

    TITLE

    Metal Ions in Neurological Systems

    ISBN

    978-3-7091-1000-3
    978-3-7091-1001-0

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-7091-1001-0_2

    DOI

    http://dx.doi.org/10.1007/978-3-7091-1001-0_2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021664252


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