The Molecular Basis of Lipid A and Toll-Like Receptor 4 Interactions View Full Text


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Chapter Info

DATE

2011-06-17

AUTHORS

Georgina L. Hold , Clare E. Bryant

ABSTRACT

In 1989 Charles Janeway proposed the concept of ‘Immune recognition’. He suggested that ‘a critical issue for future study is the analysis of microbial signals that induce second signalling capacity in antigen-presenting cells, and the receptors on antigen presenting cells that detect these microbial signals. … I term these receptors pattern recognition receptors (PRRs)’ [1]. From the early 1990s genetic studies in Drosophila and vertebrates led to the identification of the membrane associated Toll and Toll-like receptors (TLRs), the canonical PRRs predicted by Janeway. This was followed by the identification of different families of cytosolic PRRs including Retinoic acid-Inducible Gene-Like Receptors, Nucleotide Oligomerisation Domain-like receptors and Absent in melanoma-like receptors all of which play a role in pathogen recognition. More... »

PAGES

371-387

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-7091-0733-1_12

DOI

http://dx.doi.org/10.1007/978-3-7091-0733-1_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033733383


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