The Janus face of inflammation in ischemic brain injury View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2004

AUTHORS

X. Wang , G. Z. Feuerstein

ABSTRACT

Brain ischemia elicits an intense inflammatory reaction as evidenced by endogenous activation of microglia and infiltration of leukocytes from the systemic circulation into the brain. A key issue regarding the well-described inflammation in brain injury is whether this reaction is of salutary or detrimental nature in the short and longterm post ischemia. In this brief review, evidence in support for the possible beneficial as well as detrimental role of inflammatory cells and mediators in ischemic brain injury is highlighted. We offer the opinion that both benefits and adverse effects of the inflammatory reaction at large depent on the levels of a specific mediator, thtemporal relationships to the injury, the context in which the mediator operates and the spatial relationships to the injury. More... »

PAGES

49-54

Book

TITLE

Mechanisms of Secondary Brain Damage from Trauma and Ischemia

ISBN

978-3-7091-7206-3
978-3-7091-0603-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-7091-0603-7_6

DOI

http://dx.doi.org/10.1007/978-3-7091-0603-7_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004066184


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