Vaccination in Human Solid Tumors: Recent Progress in the Clinical Arena View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Giorgio Parmiani , Carolina Cimminiello , Cristina Maccalli , Vincenzo Russo

ABSTRACT

Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors. More... »

PAGES

41-46

Book

TITLE

Cancer Immunology

ISBN

978-3-662-46409-0
978-3-662-46410-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-662-46410-6_2

DOI

http://dx.doi.org/10.1007/978-3-662-46410-6_2

DIMENSIONS

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