Introduction to Aptamer and Cell-SELEX View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Libo Zhao , Weihong Tan , Xiaohong Fang

ABSTRACT

Aptamers are functional oligonucleic acids that bind to specific targets with high affinity. They have demonstrated their unique advantages as chemical antibodies in molecular recognition for many applications in biomedicine and biotechnology such as biosensing, bioimaging, and drug. In particular, a recently developed method of live cell-based in vitro selection, termed cell-SELEX, has successfully isolated aptamers without prior knowledge of a cell’s molecular signature, making such aptamers promising for applications in molecular medicine. This chapter reviews the evolution of cell-SELEX technology and introduces the content of this book, which surveys the advancements in cell-SELEX DNA aptamer selection, characterization, modification, and application for theranostics. More... »

PAGES

1-11

Book

TITLE

Aptamers Selected by Cell-SELEX for Theranostics

ISBN

978-3-662-46225-6
978-3-662-46226-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-662-46226-3_1

DOI

http://dx.doi.org/10.1007/978-3-662-46226-3_1

DIMENSIONS

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52 schema:description Aptamers are functional oligonucleic acids that bind to specific targets with high affinity. They have demonstrated their unique advantages as chemical antibodies in molecular recognition for many applications in biomedicine and biotechnology such as biosensing, bioimaging, and drug. In particular, a recently developed method of live cell-based in vitro selection, termed cell-SELEX, has successfully isolated aptamers without prior knowledge of a cell’s molecular signature, making such aptamers promising for applications in molecular medicine. This chapter reviews the evolution of cell-SELEX technology and introduces the content of this book, which surveys the advancements in cell-SELEX DNA aptamer selection, characterization, modification, and application for theranostics.
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