Inactivated Viral Vaccines View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Barbara Sanders , Martin Koldijk , Hanneke Schuitemaker

ABSTRACT

Inactivated vaccines have been used for over a century to induce protection against viral pathogens. This established approach of vaccine production is relatively straightforward to achieve and there is an augmented safety profile as compared to their live counterparts. Today, there are six viral pathogens for which licensed inactivated vaccines are available with many more in development. Here, we describe the principles of viral inactivation and the application of these principles to vaccine development. Specifically emphasized are the manufacturing procedure and the accompanying assays, of which assays used for monitoring the inactivation process and preservation of neutralizing epitopes, are pivotal. Novel inactivated vaccines in development and the hurdles they face for licensure are also discussed as well as the (dis)advantages of inactivation over the other vaccine production methodologies. More... »

PAGES

45-80

References to SciGraph publications

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  • Book

    TITLE

    Vaccine Analysis: Strategies, Principles, and Control

    ISBN

    978-3-662-45023-9
    978-3-662-45024-6

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-662-45024-6_2

    DOI

    http://dx.doi.org/10.1007/978-3-662-45024-6_2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036687119


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