Corneal Collagen Cross-Linking for Keratoconus and Corneal Ectasia View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Steven A. Greenstein , Peter S. Hersh

ABSTRACT

Corneal collagen cross-linking (CXL) is a treatment designed to decrease the progression of keratoconus, in particular, and other corneal thinning processes such as post LASIK and PRK ectasia. In addition, CXL appears to have beneficial visual and optical effects. In the CXL procedure, riboflavin (vitamin B2) is administered in conjunction with ultraviolet A (UVA 370 nm) producing a photochemical reaction in the corneal stroma with consequent mechanical stiffening of the cornea. Studies suggest that cross-linking is effective in decreasing progression of keratoconus and corneal ectasias. Maximum keratometry generally flattens by 1D to 3D 1 year after CXL. Similarly, corneal topography indices and higher-order aberrations generally improve after CXL. In addition to topography stabilization and improvement, best corrected visual acuity improves by about 1 Snellen line, on average, 1 year after CXL. After cross-linking, clinical outcomes appear to worsen at 1 month and improve between 3 and 12 months. During the wound healing course, there is a typical cross-linking-associated corneal haze, which peaks at 1 month and improves between 3 and 6 months, postoperatively. From the viewpoint of clinical decision-making, it is reasonable to consider all eyes with progressive keratoconus or corneal ectasia for cross-linking treatment; however, eyes with good visual acuity (better than 20/40) may be somewhat more susceptible to a loss of 1 Snellen line of acuity after CXL. New clinical studies are underway to investigate transepithelial and faster cross-linking procedures, as well as cross-linking as an adjunctive treatment with other procedures such as intracorneal ring segments, PRK, and microwave thermokeratoplasty (Keraflex). More... »

PAGES

71-87

Book

TITLE

Advances in Medical and Surgical Cornea

ISBN

978-3-662-44887-8
978-3-662-44888-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-662-44888-5_6

DOI

http://dx.doi.org/10.1007/978-3-662-44888-5_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005641440


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital, Newark", 
          "id": "https://www.grid.ac/institutes/grid.412547.1", 
          "name": [
            "Department of Ophthalmology, The Institute for Ophthalmology and Visual Science, Rutgers New Jersey Medical School \u2013 University Hospital, Newark, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greenstein", 
        "givenName": "Steven A.", 
        "id": "sg:person.01316570307.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316570307.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornea and Laser Eye Institute - Hersh Vision Group", 
          "id": "https://www.grid.ac/institutes/grid.488709.a", 
          "name": [
            "The Cornea and Laser Eye Institute-Hersh Vision Group, CLEI Center for Keratoconus, Teaneck, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hersh", 
        "givenName": "Peter S.", 
        "id": "sg:person.0641277407.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641277407.63"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jcrs.2006.01.091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000943664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.04-1253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003224612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2012.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003485917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2006.02.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003681354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2011.03.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006017154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9394(02)02220-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007383641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9394(02)02220-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007383641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmbbm.2008.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007722605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-3768.2008.01190.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008544225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2007.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011503078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2003.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012110520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2011.08.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012264172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clae.2006.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015399816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2013.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015603664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2010.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015741080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2010.10.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016189113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-3768.1988.tb04000.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016292106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-3768.1988.tb04000.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016292106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajo.2009.10.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016661363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ico.0000105827.85025.7f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016738607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ico.0000105827.85025.7f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016738607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000076150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017172955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2011.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019409488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ico.0b013e3182151ffc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020284277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ico.0b013e3182151ffc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020284277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ico.0b013e3182151ffc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020284277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2010.06.067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021745389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2011.11.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023923640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2007.12.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024147394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2008.09.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025238159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.07-1321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027553541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2007.07.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027758023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1442-9071.2007.01536.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027894106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2005.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028276352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ico.0000225720.38748.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029938133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ico.0000225720.38748.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029938133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003226-200401000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030017616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003226-200401000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030017616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajo.2012.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030557241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2013.03.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034044073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/opx.0b013e3181d1d940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035844297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/opx.0b013e3181d1d940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035844297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/opx.0b013e3181d1d940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035844297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2011.01.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037562957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00918483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037689365", 
          "https://doi.org/10.1007/bf00918483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0886-3350(03)00407-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039357893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0886-3350(03)00407-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039357893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2009.10.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041618323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ico.0b013e31821eea66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045338341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ico.0b013e31821eea66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045338341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jfo.2008.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045375116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ico.0b013e318190734d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045451425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ico.0b013e318190734d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045451425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.2007.130104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045495815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2007.11.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048121673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.2010.179424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049360652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2003.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050632287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.1989.01070020581044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051776905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrs.2012.01.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053120241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02713680490513182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058313728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/jop.2007.0024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059284653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3928/1081597x-20090910-02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071727021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3928/1081597x-20090910-02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071727021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3928/1081597x-20090915-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071727031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3928/1081597x-20090915-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071727031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3928/1081597x-20120518-02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071727362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5301/ejo.5000019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072750803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5301/ejo.5000019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072750803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5301/ejo.5000125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072750909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5301/ejo.5000125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072750909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074683443", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076092476", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077513119", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078129708", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082846026", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083282435", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014", 
    "datePublishedReg": "2014-01-01", 
    "description": "Corneal collagen cross-linking (CXL) is a treatment designed to decrease the progression of keratoconus, in particular, and other corneal thinning processes such as post LASIK and PRK ectasia. In addition, CXL appears to have beneficial visual and optical effects. In the CXL procedure, riboflavin (vitamin B2) is administered in conjunction with ultraviolet A (UVA 370 nm) producing a photochemical reaction in the corneal stroma with consequent mechanical stiffening of the cornea. Studies suggest that cross-linking is effective in decreasing progression of keratoconus and corneal ectasias. Maximum keratometry generally flattens by 1D to 3D 1 year after CXL. Similarly, corneal topography indices and higher-order aberrations generally improve after CXL. In addition to topography stabilization and improvement, best corrected visual acuity improves by about 1 Snellen line, on average, 1 year after CXL. After cross-linking, clinical outcomes appear to worsen at 1 month and improve between 3 and 12 months. During the wound healing course, there is a typical cross-linking-associated corneal haze, which peaks at 1 month and improves between 3 and 6 months, postoperatively. From the viewpoint of clinical decision-making, it is reasonable to consider all eyes with progressive keratoconus or corneal ectasia for cross-linking treatment; however, eyes with good visual acuity (better than 20/40) may be somewhat more susceptible to a loss of 1 Snellen line of acuity after CXL. New clinical studies are underway to investigate transepithelial and faster cross-linking procedures, as well as cross-linking as an adjunctive treatment with other procedures such as intracorneal ring segments, PRK, and microwave thermokeratoplasty (Keraflex).", 
    "editor": [
      {
        "familyName": "Jeng", 
        "givenName": "Bennie H.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-662-44888-5_6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-662-44887-8", 
        "978-3-662-44888-5"
      ], 
      "name": "Advances in Medical and Surgical Cornea", 
      "type": "Book"
    }, 
    "name": "Corneal Collagen Cross-Linking for Keratoconus and Corneal Ectasia", 
    "pagination": "71-87", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-662-44888-5_6"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1ae11fb6513cc4ba41fca1554784e1d590981e99ae26e0e951393447284472f7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005641440"
        ]
      }
    ], 
    "publisher": {
      "location": "Berlin, Heidelberg", 
      "name": "Springer Berlin Heidelberg", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-662-44888-5_6", 
      "https://app.dimensions.ai/details/publication/pub.1005641440"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T17:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000246.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-662-44888-5_6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-44888-5_6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-44888-5_6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-44888-5_6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-44888-5_6'


 

This table displays all metadata directly associated to this object as RDF triples.

250 TRIPLES      23 PREDICATES      87 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-662-44888-5_6 schema:about anzsrc-for:11
2 anzsrc-for:1113
3 schema:author N4a55dbe896b84fca828fbb731ca15cdc
4 schema:citation sg:pub.10.1007/bf00918483
5 https://app.dimensions.ai/details/publication/pub.1074683443
6 https://app.dimensions.ai/details/publication/pub.1076092476
7 https://app.dimensions.ai/details/publication/pub.1077513119
8 https://app.dimensions.ai/details/publication/pub.1078129708
9 https://app.dimensions.ai/details/publication/pub.1082846026
10 https://app.dimensions.ai/details/publication/pub.1083282435
11 https://doi.org/10.1001/archopht.1989.01070020581044
12 https://doi.org/10.1016/j.ajo.2009.10.021
13 https://doi.org/10.1016/j.ajo.2012.08.020
14 https://doi.org/10.1016/j.clae.2006.09.006
15 https://doi.org/10.1016/j.jcrs.2003.09.008
16 https://doi.org/10.1016/j.jcrs.2003.12.005
17 https://doi.org/10.1016/j.jcrs.2006.01.091
18 https://doi.org/10.1016/j.jcrs.2006.02.044
19 https://doi.org/10.1016/j.jcrs.2007.07.028
20 https://doi.org/10.1016/j.jcrs.2007.11.018
21 https://doi.org/10.1016/j.jcrs.2007.11.051
22 https://doi.org/10.1016/j.jcrs.2007.12.039
23 https://doi.org/10.1016/j.jcrs.2009.10.032
24 https://doi.org/10.1016/j.jcrs.2010.06.067
25 https://doi.org/10.1016/j.jcrs.2010.07.030
26 https://doi.org/10.1016/j.jcrs.2010.10.052
27 https://doi.org/10.1016/j.jcrs.2011.01.029
28 https://doi.org/10.1016/j.jcrs.2011.03.041
29 https://doi.org/10.1016/j.jcrs.2011.08.026
30 https://doi.org/10.1016/j.jcrs.2011.08.041
31 https://doi.org/10.1016/j.jcrs.2011.11.029
32 https://doi.org/10.1016/j.jcrs.2012.01.024
33 https://doi.org/10.1016/j.jcrs.2012.05.012
34 https://doi.org/10.1016/j.jcrs.2013.03.026
35 https://doi.org/10.1016/j.jcrs.2013.06.007
36 https://doi.org/10.1016/j.jfo.2008.11.007
37 https://doi.org/10.1016/j.jmbbm.2008.07.002
38 https://doi.org/10.1016/j.ophtha.2005.05.017
39 https://doi.org/10.1016/j.ophtha.2008.09.048
40 https://doi.org/10.1016/s0002-9394(02)02220-1
41 https://doi.org/10.1016/s0886-3350(03)00407-3
42 https://doi.org/10.1080/02713680490513182
43 https://doi.org/10.1089/jop.2007.0024
44 https://doi.org/10.1097/00003226-200401000-00008
45 https://doi.org/10.1097/01.ico.0000105827.85025.7f
46 https://doi.org/10.1097/01.ico.0000225720.38748.58
47 https://doi.org/10.1097/ico.0b013e318190734d
48 https://doi.org/10.1097/ico.0b013e3182151ffc
49 https://doi.org/10.1097/ico.0b013e31821eea66
50 https://doi.org/10.1097/opx.0b013e3181d1d940
51 https://doi.org/10.1111/j.1442-9071.2007.01536.x
52 https://doi.org/10.1111/j.1755-3768.1988.tb04000.x
53 https://doi.org/10.1111/j.1755-3768.2008.01190.x
54 https://doi.org/10.1136/bjo.2007.130104
55 https://doi.org/10.1136/bjo.2010.179424
56 https://doi.org/10.1159/000076150
57 https://doi.org/10.1167/iovs.04-1253
58 https://doi.org/10.1167/iovs.07-1321
59 https://doi.org/10.3928/1081597x-20090910-02
60 https://doi.org/10.3928/1081597x-20090915-10
61 https://doi.org/10.3928/1081597x-20120518-02
62 https://doi.org/10.5301/ejo.5000019
63 https://doi.org/10.5301/ejo.5000125
64 schema:datePublished 2014
65 schema:datePublishedReg 2014-01-01
66 schema:description Corneal collagen cross-linking (CXL) is a treatment designed to decrease the progression of keratoconus, in particular, and other corneal thinning processes such as post LASIK and PRK ectasia. In addition, CXL appears to have beneficial visual and optical effects. In the CXL procedure, riboflavin (vitamin B2) is administered in conjunction with ultraviolet A (UVA 370 nm) producing a photochemical reaction in the corneal stroma with consequent mechanical stiffening of the cornea. Studies suggest that cross-linking is effective in decreasing progression of keratoconus and corneal ectasias. Maximum keratometry generally flattens by 1D to 3D 1 year after CXL. Similarly, corneal topography indices and higher-order aberrations generally improve after CXL. In addition to topography stabilization and improvement, best corrected visual acuity improves by about 1 Snellen line, on average, 1 year after CXL. After cross-linking, clinical outcomes appear to worsen at 1 month and improve between 3 and 12 months. During the wound healing course, there is a typical cross-linking-associated corneal haze, which peaks at 1 month and improves between 3 and 6 months, postoperatively. From the viewpoint of clinical decision-making, it is reasonable to consider all eyes with progressive keratoconus or corneal ectasia for cross-linking treatment; however, eyes with good visual acuity (better than 20/40) may be somewhat more susceptible to a loss of 1 Snellen line of acuity after CXL. New clinical studies are underway to investigate transepithelial and faster cross-linking procedures, as well as cross-linking as an adjunctive treatment with other procedures such as intracorneal ring segments, PRK, and microwave thermokeratoplasty (Keraflex).
67 schema:editor Nb8a1df1cadea4fcb93515b4aa8779f99
68 schema:genre chapter
69 schema:inLanguage en
70 schema:isAccessibleForFree false
71 schema:isPartOf N75fb9497adc344a0bfa9fb8728a2c809
72 schema:name Corneal Collagen Cross-Linking for Keratoconus and Corneal Ectasia
73 schema:pagination 71-87
74 schema:productId N13417b5ec47c430d8bf54874bdad4d52
75 N4eee2bb9a3b04fd79f1ff63b8713ce1e
76 N638e2104fed8415aa89cb2241f1335c3
77 schema:publisher Nc7a1b0f40bcd4994bf2d7a1981f33f7c
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005641440
79 https://doi.org/10.1007/978-3-662-44888-5_6
80 schema:sdDatePublished 2019-04-15T17:11
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher Ne444a4caeeb84834af161ecf5419ba41
83 schema:url http://link.springer.com/10.1007/978-3-662-44888-5_6
84 sgo:license sg:explorer/license/
85 sgo:sdDataset chapters
86 rdf:type schema:Chapter
87 N13417b5ec47c430d8bf54874bdad4d52 schema:name doi
88 schema:value 10.1007/978-3-662-44888-5_6
89 rdf:type schema:PropertyValue
90 N3864fee482ce4252b09819038df3b3d6 schema:familyName Jeng
91 schema:givenName Bennie H.
92 rdf:type schema:Person
93 N409c3d36353c478f8afae705e771ad36 rdf:first sg:person.0641277407.63
94 rdf:rest rdf:nil
95 N4a55dbe896b84fca828fbb731ca15cdc rdf:first sg:person.01316570307.10
96 rdf:rest N409c3d36353c478f8afae705e771ad36
97 N4eee2bb9a3b04fd79f1ff63b8713ce1e schema:name dimensions_id
98 schema:value pub.1005641440
99 rdf:type schema:PropertyValue
100 N638e2104fed8415aa89cb2241f1335c3 schema:name readcube_id
101 schema:value 1ae11fb6513cc4ba41fca1554784e1d590981e99ae26e0e951393447284472f7
102 rdf:type schema:PropertyValue
103 N75fb9497adc344a0bfa9fb8728a2c809 schema:isbn 978-3-662-44887-8
104 978-3-662-44888-5
105 schema:name Advances in Medical and Surgical Cornea
106 rdf:type schema:Book
107 Nb8a1df1cadea4fcb93515b4aa8779f99 rdf:first N3864fee482ce4252b09819038df3b3d6
108 rdf:rest rdf:nil
109 Nc7a1b0f40bcd4994bf2d7a1981f33f7c schema:location Berlin, Heidelberg
110 schema:name Springer Berlin Heidelberg
111 rdf:type schema:Organisation
112 Ne444a4caeeb84834af161ecf5419ba41 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
115 schema:name Medical and Health Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
118 schema:name Ophthalmology and Optometry
119 rdf:type schema:DefinedTerm
120 sg:person.01316570307.10 schema:affiliation https://www.grid.ac/institutes/grid.412547.1
121 schema:familyName Greenstein
122 schema:givenName Steven A.
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316570307.10
124 rdf:type schema:Person
125 sg:person.0641277407.63 schema:affiliation https://www.grid.ac/institutes/grid.488709.a
126 schema:familyName Hersh
127 schema:givenName Peter S.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641277407.63
129 rdf:type schema:Person
130 sg:pub.10.1007/bf00918483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037689365
131 https://doi.org/10.1007/bf00918483
132 rdf:type schema:CreativeWork
133 https://app.dimensions.ai/details/publication/pub.1074683443 schema:CreativeWork
134 https://app.dimensions.ai/details/publication/pub.1076092476 schema:CreativeWork
135 https://app.dimensions.ai/details/publication/pub.1077513119 schema:CreativeWork
136 https://app.dimensions.ai/details/publication/pub.1078129708 schema:CreativeWork
137 https://app.dimensions.ai/details/publication/pub.1082846026 schema:CreativeWork
138 https://app.dimensions.ai/details/publication/pub.1083282435 schema:CreativeWork
139 https://doi.org/10.1001/archopht.1989.01070020581044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051776905
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1016/j.ajo.2009.10.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016661363
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1016/j.ajo.2012.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030557241
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1016/j.clae.2006.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015399816
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/j.jcrs.2003.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050632287
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/j.jcrs.2003.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012110520
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/j.jcrs.2006.01.091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000943664
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/j.jcrs.2006.02.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003681354
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/j.jcrs.2007.07.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027758023
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.jcrs.2007.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011503078
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.jcrs.2007.11.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048121673
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.jcrs.2007.12.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024147394
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/j.jcrs.2009.10.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041618323
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.jcrs.2010.06.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021745389
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.jcrs.2010.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015741080
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.jcrs.2010.10.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016189113
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.jcrs.2011.01.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037562957
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.jcrs.2011.03.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006017154
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.jcrs.2011.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019409488
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.jcrs.2011.08.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012264172
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.jcrs.2011.11.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023923640
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.jcrs.2012.01.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053120241
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.jcrs.2012.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003485917
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.jcrs.2013.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034044073
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.jcrs.2013.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015603664
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.jfo.2008.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045375116
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.jmbbm.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007722605
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.ophtha.2005.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028276352
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.ophtha.2008.09.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025238159
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0002-9394(02)02220-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007383641
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0886-3350(03)00407-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039357893
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1080/02713680490513182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058313728
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1089/jop.2007.0024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059284653
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1097/00003226-200401000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030017616
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1097/01.ico.0000105827.85025.7f schema:sameAs https://app.dimensions.ai/details/publication/pub.1016738607
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1097/01.ico.0000225720.38748.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029938133
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1097/ico.0b013e318190734d schema:sameAs https://app.dimensions.ai/details/publication/pub.1045451425
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/ico.0b013e3182151ffc schema:sameAs https://app.dimensions.ai/details/publication/pub.1020284277
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1097/ico.0b013e31821eea66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045338341
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1097/opx.0b013e3181d1d940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035844297
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1442-9071.2007.01536.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027894106
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/j.1755-3768.1988.tb04000.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016292106
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1111/j.1755-3768.2008.01190.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008544225
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1136/bjo.2007.130104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045495815
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1136/bjo.2010.179424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049360652
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1159/000076150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017172955
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1167/iovs.04-1253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003224612
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1167/iovs.07-1321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027553541
234 rdf:type schema:CreativeWork
235 https://doi.org/10.3928/1081597x-20090910-02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071727021
236 rdf:type schema:CreativeWork
237 https://doi.org/10.3928/1081597x-20090915-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071727031
238 rdf:type schema:CreativeWork
239 https://doi.org/10.3928/1081597x-20120518-02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071727362
240 rdf:type schema:CreativeWork
241 https://doi.org/10.5301/ejo.5000019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072750803
242 rdf:type schema:CreativeWork
243 https://doi.org/10.5301/ejo.5000125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072750909
244 rdf:type schema:CreativeWork
245 https://www.grid.ac/institutes/grid.412547.1 schema:alternateName University Hospital, Newark
246 schema:name Department of Ophthalmology, The Institute for Ophthalmology and Visual Science, Rutgers New Jersey Medical School – University Hospital, Newark, NJ, USA
247 rdf:type schema:Organization
248 https://www.grid.ac/institutes/grid.488709.a schema:alternateName Cornea and Laser Eye Institute - Hersh Vision Group
249 schema:name The Cornea and Laser Eye Institute-Hersh Vision Group, CLEI Center for Keratoconus, Teaneck, NJ, USA
250 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...