The Regulation of IL-10 Expression View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Leona Gabryšová , Ashleigh Howes , Margarida Saraiva , Anne O’Garra

ABSTRACT

Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding of how IL-10 expression is controlled is critical in the design of immune intervention strategies. IL-10 is produced by almost all cell types within the innate (including macrophages, monocytes, dendritic cells (DCs), mast cells, neutrophils, eosinophils and natural killer cells) and adaptive (including CD4(+) T cells, CD8(+) T cells and B cells) immune systems. The mechanisms of IL-10 regulation operate at several stages including chromatin remodelling at the Il10 locus, transcriptional regulation of Il10 expression and post-transcriptional regulation of Il10 mRNA. In addition, whereas some aspects of Il10 gene regulation are conserved between different immune cell types, several are cell type- or stimulus-specific. Here, we outline the complexity of IL-10 production by discussing what is known about its regulation in macrophages, monocytes, DCs and CD4(+) T helper cells. More... »

PAGES

157-90

References to SciGraph publications

  • 2013-06. Regulation of innate and adaptive immunity by Notch in NATURE REVIEWS IMMUNOLOGY
  • 2009-01. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance in NATURE IMMUNOLOGY
  • 2011-05. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells in NATURE IMMUNOLOGY
  • 2011-01. Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase in CELL RESEARCH
  • 2011-12. Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells in NATURE IMMUNOLOGY
  • 2011-03. MicroRNAs: the fine-tuners of Toll-like receptor signalling in NATURE REVIEWS IMMUNOLOGY
  • 2010-05. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors in NATURE IMMUNOLOGY
  • 2010-02. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 in NATURE IMMUNOLOGY
  • 2007-12. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells in NATURE IMMUNOLOGY
  • 2012-12. The CD46-Jagged1 interaction is critical for human TH1 immunity in NATURE IMMUNOLOGY
  • 2001-01. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation in NATURE IMMUNOLOGY
  • 2003-01. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype in NATURE
  • 2008-09. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling in NATURE IMMUNOLOGY
  • 2006-05. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function in NATURE IMMUNOLOGY
  • 2012-09-19. BATF–JUN is critical for IRF4-mediated transcription in T cells in NATURE
  • 2005-08. Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3 in NATURE IMMUNOLOGY
  • 2005-06. NFAT proteins: key regulators of T-cell development and function in NATURE REVIEWS IMMUNOLOGY
  • 2013-07. Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks in NATURE REVIEWS IMMUNOLOGY
  • 2007-12. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 in NATURE IMMUNOLOGY
  • 2004-11. Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses in NATURE IMMUNOLOGY
  • 2011-04. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells in NATURE IMMUNOLOGY
  • 2010-09. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 in NATURE IMMUNOLOGY
  • 2006-10. Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models in ONCOGENE
  • 2010-03. The regulation of IL-10 production by immune cells in NATURE REVIEWS IMMUNOLOGY
  • 2009-03. Nucleosome positioning and gene regulation: advances through genomics in NATURE REVIEWS GENETICS
  • 2013-04. T cell receptor signalling networks: branched, diversified and bounded in NATURE REVIEWS IMMUNOLOGY
  • 2011-04. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs in NATURE IMMUNOLOGY
  • 2011-03. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses in NATURE IMMUNOLOGY
  • 2006-01. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 in NATURE
  • 2008-04. Post-transcriptional control of cytokine production in NATURE IMMUNOLOGY
  • 2012-09-19. Compensatory dendritic cell development mediated by BATF–IRF interactions in NATURE
  • 2012-04. Metazoan promoters: emerging characteristics and insights into transcriptional regulation in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-662-43492-5_8

    DOI

    http://dx.doi.org/10.1007/978-3-662-43492-5_8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016431092

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25004818


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