DPA Polymorphisms in Normals, Type I Diabetics, and Patients with Graves’ Disease View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

Klaus W. J. Badenhoop , Valerie Lewis , Varina Drummond , Gisele Schwarz , John Trowsdale , Gian Franco Bottazzo

ABSTRACT

Among other organ-specific autoimmune diseases, Graves’ disease is generally associated with the serological DR3 specificity. However, the associations shown so far have not been as clear as with other autoimmune diseases and the relative risks have been calculated to be around 3 to 5. Furthermore, only 50 to 60% of patients possess the DR3 specificity. Therefore the actual disease susceptibility gene(s) are thought to be in linkage disequilibrium with genes in the human leukocyte antigen (HLA) region and might lie in the DP subregion or another on the short arm of chromosome 6. To investigate this association further at the genomic level we studied the structure of the HLA class II genes in patients with Graves’ disease, control subjects, diabetics, and families using restriction fragment length polymorphism (RFLP) analysis as well as serology. More... »

PAGES

409-410

Book

TITLE

Immunobiology of HLA

ISBN

978-3-662-38980-5
978-3-662-39946-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-662-39946-0_160

DOI

http://dx.doi.org/10.1007/978-3-662-39946-0_160

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004353173


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Department of Diabetes and Immunogenetics, St. Bartholomews Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Badenhoop", 
        "givenName": "Klaus W. J.", 
        "id": "sg:person.0675053155.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675053155.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Department of Diabetes and Immunogenetics, St. Bartholomews Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lewis", 
        "givenName": "Valerie", 
        "id": "sg:person.01173772752.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173772752.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Department of Diabetes and Immunogenetics, St. Bartholomews Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drummond", 
        "givenName": "Varina", 
        "id": "sg:person.01157633546.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157633546.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St Bartholomew's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416353.6", 
          "name": [
            "Department of Diabetes and Immunogenetics, St. Bartholomews Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwarz", 
        "givenName": "Gisele", 
        "id": "sg:person.010353225202.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010353225202.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK", 
          "id": "https://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund (ICRF), London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trowsdale", 
        "givenName": "John", 
        "id": "sg:person.0751743111.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751743111.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Immunology, Middlesex Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bottazzo", 
        "givenName": "Gian Franco", 
        "id": "sg:person.0723572726.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723572726.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1985.tb01129.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025504943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.6.1644", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028363699"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1989", 
    "datePublishedReg": "1989-01-01", 
    "description": "Among other organ-specific autoimmune diseases, Graves\u2019 disease is generally associated with the serological DR3 specificity. However, the associations shown so far have not been as clear as with other autoimmune diseases and the relative risks have been calculated to be around 3 to 5. Furthermore, only 50 to 60% of patients possess the DR3 specificity. Therefore the actual disease susceptibility gene(s) are thought to be in linkage disequilibrium with genes in the human leukocyte antigen (HLA) region and might lie in the DP subregion or another on the short arm of chromosome 6. To investigate this association further at the genomic level we studied the structure of the HLA class II genes in patients with Graves\u2019 disease, control subjects, diabetics, and families using restriction fragment length polymorphism (RFLP) analysis as well as serology.", 
    "editor": [
      {
        "familyName": "Dupont", 
        "givenName": "Bo", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-662-39946-0_160", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-662-38980-5", 
        "978-3-662-39946-0"
      ], 
      "name": "Immunobiology of HLA", 
      "type": "Book"
    }, 
    "name": "DPA Polymorphisms in Normals, Type I Diabetics, and Patients with Graves\u2019 Disease", 
    "pagination": "409-410", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-662-39946-0_160"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "14be308ce854491c0d5f283fc251b274f74885b0a501d502131735bc4d336c70"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004353173"
        ]
      }
    ], 
    "publisher": {
      "location": "Berlin, Heidelberg", 
      "name": "Springer Berlin Heidelberg", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-662-39946-0_160", 
      "https://app.dimensions.ai/details/publication/pub.1004353173"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T16:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000245.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-662-39946-0_160"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-39946-0_160'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-39946-0_160'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-39946-0_160'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-39946-0_160'


 

This table displays all metadata directly associated to this object as RDF triples.

111 TRIPLES      23 PREDICATES      29 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-662-39946-0_160 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N82d1ea0f55d740e187f0021eca44e949
4 schema:citation https://doi.org/10.1073/pnas.84.6.1644
5 https://doi.org/10.1111/j.1600-065x.1985.tb01129.x
6 schema:datePublished 1989
7 schema:datePublishedReg 1989-01-01
8 schema:description Among other organ-specific autoimmune diseases, Graves’ disease is generally associated with the serological DR3 specificity. However, the associations shown so far have not been as clear as with other autoimmune diseases and the relative risks have been calculated to be around 3 to 5. Furthermore, only 50 to 60% of patients possess the DR3 specificity. Therefore the actual disease susceptibility gene(s) are thought to be in linkage disequilibrium with genes in the human leukocyte antigen (HLA) region and might lie in the DP subregion or another on the short arm of chromosome 6. To investigate this association further at the genomic level we studied the structure of the HLA class II genes in patients with Graves’ disease, control subjects, diabetics, and families using restriction fragment length polymorphism (RFLP) analysis as well as serology.
9 schema:editor N9931b81d585544738b0db17ccef34a6e
10 schema:genre chapter
11 schema:inLanguage en
12 schema:isAccessibleForFree false
13 schema:isPartOf Nb0dbe353a5924a1d9f8940fb1ebefdf8
14 schema:name DPA Polymorphisms in Normals, Type I Diabetics, and Patients with Graves’ Disease
15 schema:pagination 409-410
16 schema:productId N3eabb891164e4f668e12ed33cb2f1bea
17 N8c370b45909c4b1cb522283e1cbae4fc
18 Na879b25c3ba140d48b19f6c4cc9b4d5e
19 schema:publisher N6a54cad53f33439eaea831a5f50522e3
20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004353173
21 https://doi.org/10.1007/978-3-662-39946-0_160
22 schema:sdDatePublished 2019-04-15T16:14
23 schema:sdLicense https://scigraph.springernature.com/explorer/license/
24 schema:sdPublisher Nd94c59b142ea4e2e86f143a45edf4845
25 schema:url http://link.springer.com/10.1007/978-3-662-39946-0_160
26 sgo:license sg:explorer/license/
27 sgo:sdDataset chapters
28 rdf:type schema:Chapter
29 N032725cea011441ab6a1569d6707b64c rdf:first sg:person.010353225202.97
30 rdf:rest Nbbff26abbb904e8eb6a81eb0a1a7a414
31 N1b3b381cf1d54a5aaa12a9cefca426b2 rdf:first sg:person.0723572726.20
32 rdf:rest rdf:nil
33 N2eefa821223b4547b2ad6a84a9bd6af3 rdf:first sg:person.01157633546.41
34 rdf:rest N032725cea011441ab6a1569d6707b64c
35 N3eabb891164e4f668e12ed33cb2f1bea schema:name readcube_id
36 schema:value 14be308ce854491c0d5f283fc251b274f74885b0a501d502131735bc4d336c70
37 rdf:type schema:PropertyValue
38 N42d08bb1555b46cebb6a6bcf0eb4ddb7 rdf:first sg:person.01173772752.07
39 rdf:rest N2eefa821223b4547b2ad6a84a9bd6af3
40 N6a54cad53f33439eaea831a5f50522e3 schema:location Berlin, Heidelberg
41 schema:name Springer Berlin Heidelberg
42 rdf:type schema:Organisation
43 N6f58c6e4eb814de3b6a80699e92cea2f schema:name Department of Immunology, Middlesex Hospital, London, UK
44 rdf:type schema:Organization
45 N82d1ea0f55d740e187f0021eca44e949 rdf:first sg:person.0675053155.92
46 rdf:rest N42d08bb1555b46cebb6a6bcf0eb4ddb7
47 N8c370b45909c4b1cb522283e1cbae4fc schema:name dimensions_id
48 schema:value pub.1004353173
49 rdf:type schema:PropertyValue
50 N9931b81d585544738b0db17ccef34a6e rdf:first Nbf0b3533c22d484da27d89d5d980a7a1
51 rdf:rest rdf:nil
52 Na879b25c3ba140d48b19f6c4cc9b4d5e schema:name doi
53 schema:value 10.1007/978-3-662-39946-0_160
54 rdf:type schema:PropertyValue
55 Nb0dbe353a5924a1d9f8940fb1ebefdf8 schema:isbn 978-3-662-38980-5
56 978-3-662-39946-0
57 schema:name Immunobiology of HLA
58 rdf:type schema:Book
59 Nbbff26abbb904e8eb6a81eb0a1a7a414 rdf:first sg:person.0751743111.42
60 rdf:rest N1b3b381cf1d54a5aaa12a9cefca426b2
61 Nbf0b3533c22d484da27d89d5d980a7a1 schema:familyName Dupont
62 schema:givenName Bo
63 rdf:type schema:Person
64 Nd94c59b142ea4e2e86f143a45edf4845 schema:name Springer Nature - SN SciGraph project
65 rdf:type schema:Organization
66 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
67 schema:name Biological Sciences
68 rdf:type schema:DefinedTerm
69 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
70 schema:name Genetics
71 rdf:type schema:DefinedTerm
72 sg:person.010353225202.97 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
73 schema:familyName Schwarz
74 schema:givenName Gisele
75 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010353225202.97
76 rdf:type schema:Person
77 sg:person.01157633546.41 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
78 schema:familyName Drummond
79 schema:givenName Varina
80 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157633546.41
81 rdf:type schema:Person
82 sg:person.01173772752.07 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
83 schema:familyName Lewis
84 schema:givenName Valerie
85 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173772752.07
86 rdf:type schema:Person
87 sg:person.0675053155.92 schema:affiliation https://www.grid.ac/institutes/grid.416353.6
88 schema:familyName Badenhoop
89 schema:givenName Klaus W. J.
90 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675053155.92
91 rdf:type schema:Person
92 sg:person.0723572726.20 schema:affiliation N6f58c6e4eb814de3b6a80699e92cea2f
93 schema:familyName Bottazzo
94 schema:givenName Gian Franco
95 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723572726.20
96 rdf:type schema:Person
97 sg:person.0751743111.42 schema:affiliation https://www.grid.ac/institutes/grid.11485.39
98 schema:familyName Trowsdale
99 schema:givenName John
100 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751743111.42
101 rdf:type schema:Person
102 https://doi.org/10.1073/pnas.84.6.1644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028363699
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1111/j.1600-065x.1985.tb01129.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025504943
105 rdf:type schema:CreativeWork
106 https://www.grid.ac/institutes/grid.11485.39 schema:alternateName Cancer Research UK
107 schema:name Imperial Cancer Research Fund (ICRF), London, UK
108 rdf:type schema:Organization
109 https://www.grid.ac/institutes/grid.416353.6 schema:alternateName St Bartholomew's Hospital
110 schema:name Department of Diabetes and Immunogenetics, St. Bartholomews Hospital, London, UK
111 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...