Expression of HLA D Subregion Genes in Thyroid Follicular Cells Transfected with SV-40+ View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

Klaus W. J. Badenhoop , Massimo Buscema , Antonino Belfiore , Ricardo Pujol-Borrell , John Trowsdale , Gian Franco Bottazzo

ABSTRACT

By transfecting HLA class II-negative thyroid cells with the plasmid px-8 containing the SV-40 early region, we obtained a continuous line of thyrocytes which maintains most of the characteristics of the parental cells. After a period of 4 months, the transfected thyrocytes showed an increased surface expression of class I molecules and a de novo expression of class II products. Different clones derived from this thyroid cell line varied in their levels of constitutive class II basal expression and also in their sensitivity to interferon-gamma (IFN-β). This phenomenon constitutes a novel mechanism of HLA class II product induction and may be relevant to explain the in vivo inappropriate class II expression described in the autoimmune and neoplastic diseases of the thyroid. More... »

PAGES

358-360

References to SciGraph publications

Book

TITLE

Immunobiology of HLA

ISBN

978-3-662-38980-5
978-3-662-39946-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-662-39946-0_137

DOI

http://dx.doi.org/10.1007/978-3-662-39946-0_137

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049305218


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