Studies on the Intercellular Junctions of Mesothelium and Endothelium View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1967

AUTHORS

R. S. Cotran , G. Majno

ABSTRACT

The passage of substances across the endothelial barrier may occur—theoretically at least [1]—by two main pathways: a) Through the cells. Particles of colloidal gold [2] or molecules of ferritin [3] injected into the plasma are taken up by the pinocytic vesicles of the endothelial cells, and thereafter appear in the extravascular spaces. This and other forms of trans-cellular passage will not be dealt within this paper. b) Between the cells. Interest in the intercellular junction as a potential pathway is stimulated by physiologic studies, which indicate that trans-endothelialpassage of ions and small molecules is a passive process. Dyes injected infra-arterially escape at discrete points along venules and capillaries [4], in a manner which could not be adequately explained by pinocytic transfer [1]. It has been stated that the endothelial cells are connected by “tight junctions” or zonulae occludenles 15, 61. It has not, however, been shown that these junctions forni a continuous band around each cell, and that they do indeed represent a tight seal. The zone of membrane “fusion” could represent, rather than a seal, a very fine filter permeable to water and to very small molecules 17, 8]. By electron microscopy, the passage of tracer particles along junctions which appeared to be still “closed” has been observed [9]: these studies were done in vitro, on rat hearts perfused with a saline solution containing particles of saccharated iron oxide (S.I.O.). More... »

PAGES

45-51

Book

TITLE

Symposium on Biophysics and Physiology of Biological Transport

ISBN

978-3-662-23148-7
978-3-662-25134-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-662-25134-8_9

DOI

http://dx.doi.org/10.1007/978-3-662-25134-8_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029447947


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Chemistry (incl. Structural)", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cotran", 
        "givenName": "R. S.", 
        "id": "sg:person.0103757776.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0103757776.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Majno", 
        "givenName": "G.", 
        "id": "sg:person.01175771661.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175771661.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.cir.24.2.368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005312006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.12.2.443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006669192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.11.3.571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007459809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.17.2.375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012480117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.23.3.553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024606550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/11.4.478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053880983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/11.4.478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053880983"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1967", 
    "datePublishedReg": "1967-01-01", 
    "description": "The passage of substances across the endothelial barrier may occur\u2014theoretically at least [1]\u2014by two main pathways: a) Through the cells. Particles of colloidal gold [2] or molecules of ferritin [3] injected into the plasma are taken up by the pinocytic vesicles of the endothelial cells, and thereafter appear in the extravascular spaces. This and other forms of trans-cellular passage will not be dealt within this paper. b) Between the cells. Interest in the intercellular junction as a potential pathway is stimulated by physiologic studies, which indicate that trans-endothelialpassage of ions and small molecules is a passive process. Dyes injected infra-arterially escape at discrete points along venules and capillaries [4], in a manner which could not be adequately explained by pinocytic transfer [1]. It has been stated that the endothelial cells are connected by \u201ctight junctions\u201d or zonulae occludenles 15, 61. It has not, however, been shown that these junctions forni a continuous band around each cell, and that they do indeed represent a tight seal. The zone of membrane \u201cfusion\u201d could represent, rather than a seal, a very fine filter permeable to water and to very small molecules 17, 8]. By electron microscopy, the passage of tracer particles along junctions which appeared to be still \u201cclosed\u201d has been observed [9]: these studies were done in vitro, on rat hearts perfused with a saline solution containing particles of saccharated iron oxide (S.I.O.).", 
    "editor": [
      {
        "familyName": "Bolis", 
        "givenName": "Liana", 
        "type": "Person"
      }, 
      {
        "familyName": "Capraro", 
        "givenName": "V.", 
        "type": "Person"
      }, 
      {
        "familyName": "Porter", 
        "givenName": "K. R.", 
        "type": "Person"
      }, 
      {
        "familyName": "Robertson", 
        "givenName": "J. D.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-662-25134-8_9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-662-23148-7", 
        "978-3-662-25134-8"
      ], 
      "name": "Symposium on Biophysics and Physiology of Biological Transport", 
      "type": "Book"
    }, 
    "name": "Studies on the Intercellular Junctions of Mesothelium and Endothelium", 
    "pagination": "45-51", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-662-25134-8_9"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8c48e16567fe32d740d6df32ba58991ff321398002cb403ab25934fbed416e33"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029447947"
        ]
      }
    ], 
    "publisher": {
      "location": "Berlin, Heidelberg", 
      "name": "Springer Berlin Heidelberg", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-662-25134-8_9", 
      "https://app.dimensions.ai/details/publication/pub.1029447947"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T21:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000261.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-662-25134-8_9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-25134-8_9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-25134-8_9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-25134-8_9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-662-25134-8_9'


 

This table displays all metadata directly associated to this object as RDF triples.

105 TRIPLES      23 PREDICATES      33 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-662-25134-8_9 schema:about anzsrc-for:03
2 anzsrc-for:0306
3 schema:author N8d7744714a0245dcb723cf80f800a90d
4 schema:citation https://doi.org/10.1083/jcb.11.3.571
5 https://doi.org/10.1083/jcb.12.2.443
6 https://doi.org/10.1083/jcb.17.2.375
7 https://doi.org/10.1083/jcb.23.3.553
8 https://doi.org/10.1161/01.cir.24.2.368
9 https://doi.org/10.1177/11.4.478
10 schema:datePublished 1967
11 schema:datePublishedReg 1967-01-01
12 schema:description The passage of substances across the endothelial barrier may occur—theoretically at least [1]—by two main pathways: a) Through the cells. Particles of colloidal gold [2] or molecules of ferritin [3] injected into the plasma are taken up by the pinocytic vesicles of the endothelial cells, and thereafter appear in the extravascular spaces. This and other forms of trans-cellular passage will not be dealt within this paper. b) Between the cells. Interest in the intercellular junction as a potential pathway is stimulated by physiologic studies, which indicate that trans-endothelialpassage of ions and small molecules is a passive process. Dyes injected infra-arterially escape at discrete points along venules and capillaries [4], in a manner which could not be adequately explained by pinocytic transfer [1]. It has been stated that the endothelial cells are connected by “tight junctions” or zonulae occludenles 15, 61. It has not, however, been shown that these junctions forni a continuous band around each cell, and that they do indeed represent a tight seal. The zone of membrane “fusion” could represent, rather than a seal, a very fine filter permeable to water and to very small molecules 17, 8]. By electron microscopy, the passage of tracer particles along junctions which appeared to be still “closed” has been observed [9]: these studies were done in vitro, on rat hearts perfused with a saline solution containing particles of saccharated iron oxide (S.I.O.).
13 schema:editor Ne2c1398323254fd49dd0bd1ff8d1ecb5
14 schema:genre chapter
15 schema:inLanguage en
16 schema:isAccessibleForFree false
17 schema:isPartOf N28ab5b68eec74ea5953791d42bd33e3a
18 schema:name Studies on the Intercellular Junctions of Mesothelium and Endothelium
19 schema:pagination 45-51
20 schema:productId N031f5d69cce34f10ac1c19937dca2adf
21 N2d269db34a78445ca9254e3c09aa6df1
22 N654a08c84af741f5bd93726728910d49
23 schema:publisher Na4262aeb4b9b4fc98a1cfd8da20a4505
24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029447947
25 https://doi.org/10.1007/978-3-662-25134-8_9
26 schema:sdDatePublished 2019-04-15T21:59
27 schema:sdLicense https://scigraph.springernature.com/explorer/license/
28 schema:sdPublisher N36904caec5d342fbb69dcd3d52be6eca
29 schema:url http://link.springer.com/10.1007/978-3-662-25134-8_9
30 sgo:license sg:explorer/license/
31 sgo:sdDataset chapters
32 rdf:type schema:Chapter
33 N031f5d69cce34f10ac1c19937dca2adf schema:name readcube_id
34 schema:value 8c48e16567fe32d740d6df32ba58991ff321398002cb403ab25934fbed416e33
35 rdf:type schema:PropertyValue
36 N1a9c199f72744ff3b4074bda1ecf8b30 rdf:first N3b35a2d1e26a41979eac64187bf30354
37 rdf:rest N6ca6dec2ea8a4517b2482174d028c365
38 N28ab5b68eec74ea5953791d42bd33e3a schema:isbn 978-3-662-23148-7
39 978-3-662-25134-8
40 schema:name Symposium on Biophysics and Physiology of Biological Transport
41 rdf:type schema:Book
42 N2d269db34a78445ca9254e3c09aa6df1 schema:name doi
43 schema:value 10.1007/978-3-662-25134-8_9
44 rdf:type schema:PropertyValue
45 N36904caec5d342fbb69dcd3d52be6eca schema:name Springer Nature - SN SciGraph project
46 rdf:type schema:Organization
47 N3b35a2d1e26a41979eac64187bf30354 schema:familyName Porter
48 schema:givenName K. R.
49 rdf:type schema:Person
50 N4238add3b028462da9fd961b7d81f7d9 schema:familyName Bolis
51 schema:givenName Liana
52 rdf:type schema:Person
53 N560bedd823504867803758ccf53ff4ea rdf:first Nd24d58ab20f847a49f4eed99febd02fe
54 rdf:rest N1a9c199f72744ff3b4074bda1ecf8b30
55 N6357dd0521ae4ec49273910fcf798507 rdf:first sg:person.01175771661.61
56 rdf:rest rdf:nil
57 N654a08c84af741f5bd93726728910d49 schema:name dimensions_id
58 schema:value pub.1029447947
59 rdf:type schema:PropertyValue
60 N6ca6dec2ea8a4517b2482174d028c365 rdf:first N6d207df5731048dc899415da6e2d89cc
61 rdf:rest rdf:nil
62 N6d207df5731048dc899415da6e2d89cc schema:familyName Robertson
63 schema:givenName J. D.
64 rdf:type schema:Person
65 N8d7744714a0245dcb723cf80f800a90d rdf:first sg:person.0103757776.86
66 rdf:rest N6357dd0521ae4ec49273910fcf798507
67 Na4262aeb4b9b4fc98a1cfd8da20a4505 schema:location Berlin, Heidelberg
68 schema:name Springer Berlin Heidelberg
69 rdf:type schema:Organisation
70 Nd24d58ab20f847a49f4eed99febd02fe schema:familyName Capraro
71 schema:givenName V.
72 rdf:type schema:Person
73 Ne2c1398323254fd49dd0bd1ff8d1ecb5 rdf:first N4238add3b028462da9fd961b7d81f7d9
74 rdf:rest N560bedd823504867803758ccf53ff4ea
75 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
76 schema:name Chemical Sciences
77 rdf:type schema:DefinedTerm
78 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
79 schema:name Physical Chemistry (incl. Structural)
80 rdf:type schema:DefinedTerm
81 sg:person.0103757776.86 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
82 schema:familyName Cotran
83 schema:givenName R. S.
84 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0103757776.86
85 rdf:type schema:Person
86 sg:person.01175771661.61 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
87 schema:familyName Majno
88 schema:givenName G.
89 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175771661.61
90 rdf:type schema:Person
91 https://doi.org/10.1083/jcb.11.3.571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007459809
92 rdf:type schema:CreativeWork
93 https://doi.org/10.1083/jcb.12.2.443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006669192
94 rdf:type schema:CreativeWork
95 https://doi.org/10.1083/jcb.17.2.375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012480117
96 rdf:type schema:CreativeWork
97 https://doi.org/10.1083/jcb.23.3.553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024606550
98 rdf:type schema:CreativeWork
99 https://doi.org/10.1161/01.cir.24.2.368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005312006
100 rdf:type schema:CreativeWork
101 https://doi.org/10.1177/11.4.478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053880983
102 rdf:type schema:CreativeWork
103 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
104 schema:name Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
105 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...