Mechanisms of Action of Bisphosphonates as Inhibitors of Bone Resorption View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

Paul T. Sharpe , Michael J. Rogers , R. Graham G. Russell

ABSTRACT

More than 25 years have passed since it was first recognized that bisphosphonates could inhibit bone resorption.1–3 During this time, bisphosphonates have become the treatment of choice for a variety of bone diseases in which excessive osteoclast activity is an important pathological feature, including Paget’s disease of bone,4 metastatic and osteolytic bone disease, hypercalcemia of malignancy5 and, more recently, postmenopausal and other forms of osteoporosis (Fig. 7.1).6,7 However, despite the widespread clinical use of bisphosphonates, their exact mechanism of action, at both the cellular and molecular level, have not been clearly identified. More... »

PAGES

147-177

References to SciGraph publications

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  • Book

    TITLE

    The Molecular Biology of Paget’s Disease

    ISBN

    978-3-662-22507-3
    978-3-662-22505-9

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-662-22505-9_7

    DOI

    http://dx.doi.org/10.1007/978-3-662-22505-9_7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052420902


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