IL-10 and HIV-1 Replication View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

Hanneke Schuitemaker , Neeltje A. Kootstra , Frank Miedema

ABSTRACT

The human immunodeficiency virus type 1 (HIV-1) causes the acquired immunodeficiency syndrome which is characterized by a gradual depletion of CD4+ T cells. Understanding which factors determine the rate of progression of HIV-1 infection is one of the major goals of current AIDS pathogenesis research. Biological variability of HIV-1 may be one of the factors that contribute to the differential course of infection. Biological properties with respect to which HIV-1 isolates can differ are for instance syncytium inducing (SI) capacity, replication rate and cytotropism.1–5 HIV-1 isolates recovered from peripheral blood mononuclear cells of asymptomatic subjects are able to grow in phytohaemagglutinin (PHA) stimulated primary blood lymphocytes (PBL) but cannot be transmitted to cell lines, replicate relatively slowly and are non-syncytium inducing.5 Primary virus isolation from approximately 50% of patients with AIDS related complex (ARC) or AIDS on PHA stimulated PBL results in the isolation of T-cell-line-tropic SI isolates. SI variants generally emerge during the course of infection and eventually are detected in about half of infected individuals with advanced disease.6–8 More... »

PAGES

101-112

Book

TITLE

Interleukin-10

ISBN

978-3-662-22040-5
978-3-662-22038-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-662-22038-2_11

DOI

http://dx.doi.org/10.1007/978-3-662-22038-2_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004183531


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