Control of B Lymphocyte Activation Through Reversible Binding of Multivalent Antigen: A Simple Model View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1979

AUTHORS

A. Gandolfi , M. A. Giovenco , R. Strom

ABSTRACT

With respect to the problem of the stimulation of B lymphocytes, several authors [1–5] have hypothesized that activation requires the formation of a receptor lattice on the cell surface through the binding of a matrix of antigenic determinants, simple occupancy of receptors by antigenic determinants being inadequate. Moreover, even if it is assumed that the triggering signal for B cell activation be some kind of interaction of the carrier portion of antigen with the immunocompetent cells [6], multiple binding of antigenic determinants still appears to be needed in order to ensure a stable adhesion of the antigen molecule to the cell surface. More... »

PAGES

37-51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-93130-7_4

DOI

http://dx.doi.org/10.1007/978-3-642-93130-7_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036815566


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