Growth Regulation in Normal and Malignant Melanocytes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

R. Halaban

ABSTRACT

The biochemical events responsible for the progression of normal melanocytes into preneoplastic cells, such as in dysplastic nevi, and further on into early malignant state such as in thin-radial melanoma, into nodular melanoma and culminating in metastatic disease are not yet known. One of the most common characteristics of melanoma cells grown in vitro from nodular primary or metastatic melanoma lesions is an acquired autonomy from growth factors required by their normal counterparts and possibly by melanocytes from primary melanomas of the radial growth phase. In view of the fact that normal human melanocytes depend on several growth factors, it is possible that progression to melanoma is due to inappropriate production of one or more of these factors, to mutations that cause constitutive activation of the receptors for these growth factors, or to constitutive activation of other components of the signal transduction pathway. Therefore knowledge of growth factors/receptors and their substrates operative in normal human melanocytes may provide clues for the biochemical basis of transformation to melanomas. The following review focuses on growth factor and receptor activity in normal and malignant melanocytes. More... »

PAGES

133-150

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-84881-0_10

DOI

http://dx.doi.org/10.1007/978-3-642-84881-0_10

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007722010

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8356315


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