Platelet Activating Factor: Rationale for the Use of PAF-Antagonists in Sepsis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1992

AUTHORS

J. P. Mira , J. F. Dhainaut , F. Brunet

ABSTRACT

Septic shock, especially due to gram-negative infection, continues to be an increasingly serious clinical problem carrying high mortality rate despite significant advances in antimicrobial therapeutics [1]. Moreover, this treatment has little effect on endotoxin (LPS), and may even promote the release of LPS from bacteria [2]. Release of LPS or other bacterial debris activate various humoral and cellular cascades which result in an effective defense against infection [3]. In many cases, however, this response becomes exaggerated causing tissue damage [4, 5]. These host defense systems include complement, kinin and clotting cascades with activation of macrophages and various leukocytes [3]. These cells, in turn, release several potent mediators. More... »

PAGES

377-392

Book

TITLE

Mediators of Sepsis

ISBN

978-3-642-84829-2
978-3-642-84827-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-84827-8_27

DOI

http://dx.doi.org/10.1007/978-3-642-84827-8_27

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009243273


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