Evolution of New World Primate MHC Class I Genes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

D. I. Watkins , T. L. Garber , Z. W. Chen , A. L. Hughes , N. L. Letvin

ABSTRACT

We cloned, sequenced and transfected the MHC class I genes from three other species of bone-chimeric primates (the saddle-backed tamarin, S. fuscicollis; the common marmoset, Callithrix jacehus; and the golden-headed lion tamarin, Leontopithecus rosalia) and a single species of a non-bone marrow-chimeric New World primate (the owl monkey, Aotus trivirqatus). The MHC class I genes of the bone marrow-chimeric species all displayed low levels of MHC class I variation; the MHC class I genes of the non-bone marrow-chimeric A.trivirqatus were highly variable. This finding suggests that bone marrow-chimerism may indeed be related to a reduction in MHC class I variation in New World primates. To investigate the relatedness of these New World primate MHC class I genes, gene trees were constructed. All of the New World primate classical MHC class I genes, including those of A.trivirqatus, were related to the human non-clasical HLA-G gene. The S.fuscicollis MHC class I genes were indistinguishable from those of S.oedipus. Surprisingly, the MHC class I genes of C.jacchus were only distantly related to the MHC class I genes of S.oedipus and S.fuscicollis. Interestingly, the functional MHC class I genes of C.jacchus were closely related to two pseudo genes of S.oedipus. These data suggest that MHC class I evolution in New World primates may take place by duplication and subsequent inactivation or expansion of certain genes. More... »

PAGES

177-191

Book

TITLE

Molecular Evolution of the Major Histocompatibility Complex

ISBN

978-3-642-84624-3
978-3-642-84622-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-84622-9_15

DOI

http://dx.doi.org/10.1007/978-3-642-84622-9_15

DIMENSIONS

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