Differential Activation of Homeobox Genes by Retinoic Acid in Human Embryonal Carcinoma Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

L. Bottero , A. Simeone , L. Arcioni , D. Acampora , P. W. Andrews , E. Boncinelli , F. Mavilio

ABSTRACT

Morphogens, i.e., endogenous, diffusible molecules which induce pathways of differentiation through a gradient of concentration, play a key role in vertebrate development. Retinoic acid (RA) is a natural morphogen in chicken development, where it specifies the limb anteroposterior (AP) axis (Tickle et al. 1982; Thaller and Eichele 1987, 1988; Brockes 1989), and possibly in frogs, where alteration of intraembryonic RA levels dramatically affects the AP polarity of the developing CNS (Durston et al., 1989). The identification of three nuclear RA receptors in mouse and man (Petkovich et al. 1987; Giguere et al. 1987; Brand et al. 1988; Zelent et al. 1989) supports the concept that the morphogens act as intracellular signal molecules with direct gene control functions. Although the genes involved in transducing signals provided by morphogens are still unknown, homeobox genes, which specify positional information in Drosophila and possibly in vertebrate embryogenesis (Gehring 1987; Ingham 1988; Holland and Hogan 1988), are among the suggested candidates (Brockes 1989; de Robertis et al. 1989). More... »

PAGES

133-43

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-84485-0_15

DOI

http://dx.doi.org/10.1007/978-3-642-84485-0_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050700577

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1684061


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