The Value of Preoperative Radiotherapy in Esophageal Cancer: Results of a Study by the EORTC View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

M. Gignoux , A. Roussel , B. Paillot , M. Gillet , P. Schlag , O. Dalesio , M. Buyse , N. Duez

ABSTRACT

Attempts to combine radiation therapy and surgery in operable patients with carcinoma of the esophagus started 30 years ago. The first reported surgical series showed a low rate of resectability and a high postoperative mortality. Results of radiation therapy alone were also disappointing in the long run, especially in patients who appeared to be excellent operative risks with small localized tumors. The rationale for a combined approach was that X-ray therapy could bring about a reduction of tumor activity and bulk, an improvement in nutritional state through the restoration of the ability to swallow, a reduction of transplantability of the tumor, and a curative effect on periesophageal regional disease, which is not treated well by surgery. On the other hand, surgery often allowed an extended resection, clearing residual foci or distant esophageal wall extension. The limitation of a combined approach is the toxicity of the preoperative radiation, which must be mild enough to allow surgery to proceed without excessive delay or increased mortality. Numerous radiotherapy schedules were tried using different fields, doses, and fractionations, most of them in nonrandomized studies. Two prospective randomized trials have recently been reported. The final results of a third prospective trial, run by the E.O.R.T.C*, will be presented. More... »

PAGES

1-13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-83293-2_1

DOI

http://dx.doi.org/10.1007/978-3-642-83293-2_1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038740620

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3043582


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