Klinische Anwendung der Positronen-Emissionstomographie View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

J. Fitschen , F. Helus , K. Jordan , D. Junker , G.-J. Meyer , O. Schober , G. Stöcklin

ABSTRACT

In der nuklearmedizinischen Diagnostik werden seit über 40 Jahren Radionuklide mit großem Erfolg eingesetzt. Sie finden entweder direkte Anwendung in einfachen anorganischen Formen oder dienen zur Markierung körpereigener Substanzen und geeigneter Pharmaka. Um optimal und routinemäßig in der Diagnostik eingesetzt werden zu können, müssen die Radionuklide bestimmte Voraussetzungen bezüglich ihrer physikalischen Eigenschaften aufweisen. Dazu gehören im wesentlichen eine gute Verfügbarkeit und eine gute Meßmethodik. Darüber hinaus müssen die Strahlungsart und die damit verbundene spezifische Dosisleistung des Nuklid, dem Anwendungszweck möglichst gut angepaßt sein. Nuklide mit Halbwertzeiten unter 12 Stunden sind im allgemeinen nur dann für die Routinediagnostik ausreichend verfügbar, wenn sie über Generatorsysteme mit entsprechend langer Halbwertzeit hergestellt werden können. Um mit dem in der nuklearmedizinischen Diagnostik am weitesten verbreiteten Meßsystem, der Angerkamera, detektiert werden zu können, muß die emittierte Gammastrahlung im Bereich von 80–300 keV liegen. Weil es keine Radionuklide der wichtigsten physiologisch-organischen Elemente Kohlenstoff (C), Stickstoff (N) und Sauerstoff (O) gibt, die diese Voraussetzungen erfüllen, war es bis vor kurzem nicht möglich, entsprechend markierte Radiopharmaka zur Diagnostik einzusetzen. More... »

PAGES

315-469

References to SciGraph publications

Book

TITLE

Nuklearmedizin / Nuclear Medicine

ISBN

978-3-642-83147-8
978-3-642-83146-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-83146-1_5

DOI

http://dx.doi.org/10.1007/978-3-642-83146-1_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018801356


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575 schema:description In der nuklearmedizinischen Diagnostik werden seit über 40 Jahren Radionuklide mit großem Erfolg eingesetzt. Sie finden entweder direkte Anwendung in einfachen anorganischen Formen oder dienen zur Markierung körpereigener Substanzen und geeigneter Pharmaka. Um optimal und routinemäßig in der Diagnostik eingesetzt werden zu können, müssen die Radionuklide bestimmte Voraussetzungen bezüglich ihrer physikalischen Eigenschaften aufweisen. Dazu gehören im wesentlichen eine gute Verfügbarkeit und eine gute Meßmethodik. Darüber hinaus müssen die Strahlungsart und die damit verbundene spezifische Dosisleistung des Nuklid, dem Anwendungszweck möglichst gut angepaßt sein. Nuklide mit Halbwertzeiten unter 12 Stunden sind im allgemeinen nur dann für die Routinediagnostik ausreichend verfügbar, wenn sie über Generatorsysteme mit entsprechend langer Halbwertzeit hergestellt werden können. Um mit dem in der nuklearmedizinischen Diagnostik am weitesten verbreiteten Meßsystem, der Angerkamera, detektiert werden zu können, muß die emittierte Gammastrahlung im Bereich von 80–300 keV liegen. Weil es keine Radionuklide der wichtigsten physiologisch-organischen Elemente Kohlenstoff (C), Stickstoff (N) und Sauerstoff (O) gibt, die diese Voraussetzungen erfüllen, war es bis vor kurzem nicht möglich, entsprechend markierte Radiopharmaka zur Diagnostik einzusetzen.
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