Etiology of Small Cell Lung Carcinoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

W. J. Zeller , D. Schmähl

ABSTRACT

With regard to morphology, biology, and therapy it seems justified to consider small cell lung carcinoma (SCLC) separately from the other main forms of lung carcinoma (squamous cell, adenocarcinoma, large cell). This is expressed by the rough division of lung cancers into the small cell and non-small-cell groups. Regarding etiology, however, a separation of small cell carcinoma from the other types seems not to be justifiable and extremely difficult. Kreyberg (1962) has already combined squamous cell and small cell carcinomas into “group I tumors,” pointing out that these types have common causative factors, especially environmental carcinogens, including tobacco smoking, occupational hazards, and ionizing radiation. In recent years the “unitarian” theory of the origin of lung cancers, suggesting a common stem cell, has been revived and is replacing the theory of a separate histogenesis of SCLC from the neural crest. Biochemical investigations have revealed that the l-dopa decarboxylase, the key enzyme of the so-called APUD tumors (Pearse 1969), can be detected not only in SCLC but, though at lower levels, in any morphological type of lung cancer (Baylin and Gazdar 1981). Both in lung cancer cultures and in patients (at relapse) a morphological conversion from SCLC to non-SCLC histology has been observed (Gazdar et al. 1981; Fer et al. 1983). It is therefore not surprising that most lung carcinogens are associated with more or less the entire spectrum of lung cancer types in man. More... »

PAGES

1-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-82372-5_1

DOI

http://dx.doi.org/10.1007/978-3-642-82372-5_1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024712254

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2986236


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