Mode of Action View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

A. Maxwell , S. E. Critchlow

ABSTRACT

Over recent years there has been an enormous explosion of interest in the quinolone drugs in general and the fluoroquinolones in particular. This is manifested by the production of this volume and other works on this subject (e.g. Fernandes 1989; Crumplin 1990; Siporin et al. 1990; Hooper and Wolfson 1993a). Details of the structures of a wide range of quinolones will be found elsewhere in this book, but the structures of the principal quinolones mentioned in this chapter are shown in Fig. 1. In this chapter, we discuss the mode of action of quinolones, i.e. how they are thought to act on their intracellular target, DNA gyrase. Other recent reviews which cover this topic include those by Drlica et al. (1990, 1995), Hooper and Wolfson (1991, 1993b), Reece and Maxwell (1991a), Maxwell (1992) and Palumbo et al. (1993). It is worth noting at this point the existence of a second target, DNA topoisomerase IV, which is discussed below. Before describing the effects of quinolones on bacteria and on gyrase, we will discuss the basic properties of DNA gyrase. More... »

PAGES

119-166

Book

TITLE

Quinolone Antibacterials

ISBN

978-3-642-80366-6
978-3-642-80364-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-80364-2_4

DOI

http://dx.doi.org/10.1007/978-3-642-80364-2_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045617134


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Maxwell", 
        "givenName": "A.", 
        "id": "sg:person.01274446176.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274446176.29"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Critchlow", 
        "givenName": "S. E.", 
        "id": "sg:person.01347402732.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347402732.18"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998", 
    "datePublishedReg": "1998-01-01", 
    "description": "Over recent years there has been an enormous explosion of interest in the quinolone drugs in general and the fluoroquinolones in particular. This is manifested by the production of this volume and other works on this subject (e.g. Fernandes 1989; Crumplin 1990; Siporin et al. 1990; Hooper and Wolfson 1993a). Details of the structures of a wide range of quinolones will be found elsewhere in this book, but the structures of the principal quinolones mentioned in this chapter are shown in Fig. 1. In this chapter, we discuss the mode of action of quinolones, i.e. how they are thought to act on their intracellular target, DNA gyrase. Other recent reviews which cover this topic include those by Drlica et al. (1990, 1995), Hooper and Wolfson (1991, 1993b), Reece and Maxwell (1991a), Maxwell (1992) and Palumbo et al. (1993). It is worth noting at this point the existence of a second target, DNA topoisomerase IV, which is discussed below. Before describing the effects of quinolones on bacteria and on gyrase, we will discuss the basic properties of DNA gyrase.", 
    "editor": [
      {
        "familyName": "Kuhlmann", 
        "givenName": "J.", 
        "type": "Person"
      }, 
      {
        "familyName": "Dalhoff", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Zeiler", 
        "givenName": "H.-J.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-642-80364-2_4", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-642-80366-6", 
        "978-3-642-80364-2"
      ], 
      "name": "Quinolone Antibacterials", 
      "type": "Book"
    }, 
    "keywords": [
      "DNA gyrase", 
      "mode of action", 
      "DNA topoisomerase IV", 
      "topoisomerase IV", 
      "intracellular targets", 
      "gyrase", 
      "effects of quinolones", 
      "quinolone drugs", 
      "target", 
      "bacteria", 
      "recent review", 
      "wide range", 
      "enormous explosion", 
      "production", 
      "quinolones", 
      "structure", 
      "action", 
      "Fig. 1", 
      "Palumbo et al", 
      "recent years", 
      "chapter", 
      "review", 
      "basic properties", 
      "al", 
      "existence", 
      "properties", 
      "range", 
      "mode", 
      "second target", 
      "effect", 
      "interest", 
      "et al", 
      "drugs", 
      "fluoroquinolones", 
      "detail", 
      "years", 
      "Hooper", 
      "explosion", 
      "work", 
      "volume", 
      "Reece", 
      "point", 
      "topic", 
      "subjects", 
      "book", 
      "Maxwell", 
      "Wolfson", 
      "principal quinolones", 
      "Drlica et al"
    ], 
    "name": "Mode of Action", 
    "pagination": "119-166", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045617134"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-642-80364-2_4"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-642-80364-2_4", 
      "https://app.dimensions.ai/details/publication/pub.1045617134"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2021-11-01T18:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/chapter/chapter_39.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-3-642-80364-2_4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-80364-2_4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-80364-2_4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-80364-2_4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-80364-2_4'


 

This table displays all metadata directly associated to this object as RDF triples.

121 TRIPLES      23 PREDICATES      74 URIs      67 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-642-80364-2_4 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N306e035fe47a49f7b11d2d92be80ce04
4 schema:datePublished 1998
5 schema:datePublishedReg 1998-01-01
6 schema:description Over recent years there has been an enormous explosion of interest in the quinolone drugs in general and the fluoroquinolones in particular. This is manifested by the production of this volume and other works on this subject (e.g. Fernandes 1989; Crumplin 1990; Siporin et al. 1990; Hooper and Wolfson 1993a). Details of the structures of a wide range of quinolones will be found elsewhere in this book, but the structures of the principal quinolones mentioned in this chapter are shown in Fig. 1. In this chapter, we discuss the mode of action of quinolones, i.e. how they are thought to act on their intracellular target, DNA gyrase. Other recent reviews which cover this topic include those by Drlica et al. (1990, 1995), Hooper and Wolfson (1991, 1993b), Reece and Maxwell (1991a), Maxwell (1992) and Palumbo et al. (1993). It is worth noting at this point the existence of a second target, DNA topoisomerase IV, which is discussed below. Before describing the effects of quinolones on bacteria and on gyrase, we will discuss the basic properties of DNA gyrase.
7 schema:editor Nd48911853f2d4b94a805dbf3fa48ddad
8 schema:genre chapter
9 schema:inLanguage en
10 schema:isAccessibleForFree false
11 schema:isPartOf Nadf3c2ed880d4701ac568b35cc2b333c
12 schema:keywords DNA gyrase
13 DNA topoisomerase IV
14 Drlica et al
15 Fig. 1
16 Hooper
17 Maxwell
18 Palumbo et al
19 Reece
20 Wolfson
21 action
22 al
23 bacteria
24 basic properties
25 book
26 chapter
27 detail
28 drugs
29 effect
30 effects of quinolones
31 enormous explosion
32 et al
33 existence
34 explosion
35 fluoroquinolones
36 gyrase
37 interest
38 intracellular targets
39 mode
40 mode of action
41 point
42 principal quinolones
43 production
44 properties
45 quinolone drugs
46 quinolones
47 range
48 recent review
49 recent years
50 review
51 second target
52 structure
53 subjects
54 target
55 topic
56 topoisomerase IV
57 volume
58 wide range
59 work
60 years
61 schema:name Mode of Action
62 schema:pagination 119-166
63 schema:productId N5d729c4ed2db4c5d91504fbfb3f0e21a
64 N8fe9a94e3afb4aab844d4157c915f757
65 schema:publisher Nd2114bc9e5ab4551909e0d67aefa5c3d
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045617134
67 https://doi.org/10.1007/978-3-642-80364-2_4
68 schema:sdDatePublished 2021-11-01T18:58
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N537ea1f05d34451e99554a8a373658d4
71 schema:url https://doi.org/10.1007/978-3-642-80364-2_4
72 sgo:license sg:explorer/license/
73 sgo:sdDataset chapters
74 rdf:type schema:Chapter
75 N306e035fe47a49f7b11d2d92be80ce04 rdf:first sg:person.01274446176.29
76 rdf:rest Nf4fa40858d0e4e63bb4610bc16d71688
77 N4ff9e64ba4b74f47ac317849a9d81787 rdf:first N73c4c273e0d64765ada529388f6f8e47
78 rdf:rest N92a9d1c51b9141e698e10d2d45ad2851
79 N537ea1f05d34451e99554a8a373658d4 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N5d729c4ed2db4c5d91504fbfb3f0e21a schema:name dimensions_id
82 schema:value pub.1045617134
83 rdf:type schema:PropertyValue
84 N73c4c273e0d64765ada529388f6f8e47 schema:familyName Dalhoff
85 schema:givenName A.
86 rdf:type schema:Person
87 N8fe9a94e3afb4aab844d4157c915f757 schema:name doi
88 schema:value 10.1007/978-3-642-80364-2_4
89 rdf:type schema:PropertyValue
90 N92a9d1c51b9141e698e10d2d45ad2851 rdf:first Nb6650c194b9d4bdf88fef22cfca618ed
91 rdf:rest rdf:nil
92 Nadf3c2ed880d4701ac568b35cc2b333c schema:isbn 978-3-642-80364-2
93 978-3-642-80366-6
94 schema:name Quinolone Antibacterials
95 rdf:type schema:Book
96 Nb6650c194b9d4bdf88fef22cfca618ed schema:familyName Zeiler
97 schema:givenName H.-J.
98 rdf:type schema:Person
99 Nd2114bc9e5ab4551909e0d67aefa5c3d schema:name Springer Nature
100 rdf:type schema:Organisation
101 Nd48911853f2d4b94a805dbf3fa48ddad rdf:first Nfc1508f102b642d1b13c5ea041911274
102 rdf:rest N4ff9e64ba4b74f47ac317849a9d81787
103 Nf4fa40858d0e4e63bb4610bc16d71688 rdf:first sg:person.01347402732.18
104 rdf:rest rdf:nil
105 Nfc1508f102b642d1b13c5ea041911274 schema:familyName Kuhlmann
106 schema:givenName J.
107 rdf:type schema:Person
108 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
109 schema:name Biological Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
112 schema:name Biochemistry and Cell Biology
113 rdf:type schema:DefinedTerm
114 sg:person.01274446176.29 schema:familyName Maxwell
115 schema:givenName A.
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274446176.29
117 rdf:type schema:Person
118 sg:person.01347402732.18 schema:familyName Critchlow
119 schema:givenName S. E.
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347402732.18
121 rdf:type schema:Person
 




Preview window. Press ESC to close (or click here)


...