Multiple Developmental Functions of the Zinc Finger Gene Krox-20 Are Revealed by Targeted Insertion of the E. coli lacZ Coding ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

Sylvie Schneider-Maunoury , Piotr Topilko , Tania Seitanidou , Giovanni Levi , Paula Murphy , Patrick Charnay

ABSTRACT

The inactivation of the Krox-20 gene in the mouse has allowed us to study the involvement of this gene in the regulation of several processes as diverse as hindbrain segmentation, peripheral nervous system (PNS) myelination and endochondral bone formation (Schneider-Maunoury et al. 1993; Topilko et al. 1994; Levi et al. 1996). The aim of the present chapter is to describe the procedure we selected to inactivate the Krox-20 gene and to show how this strategy, which involved the use of a lacZ tracer gene, has helped us in understanding the phenotypes associated with the mutation and has enabled us to discover novel Krox-20 functions. More... »

PAGES

459-476

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-80343-7_25

DOI

http://dx.doi.org/10.1007/978-3-642-80343-7_25

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005099369


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