DNA Branch Migration View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

P. Hsieh , I. G. Panyutin

ABSTRACT

DNA branch migration involves the exchange of one DNA strand for another by the stepwise breakage and reformation of hydrogen bonds in DNA duplexes. In four-strand branch migration the cross-over point between two duplexes is known as the Holliday junction. If the duplex sequences flanking the Holliday junction are identical, the junction can move in either direction by the exchange of hydrogen bonds between two DNA strands of the same polarity (Fig. 1, top). Branch migration involving three-strand reactions, sometimes referred to as single-strand branch migration, can also occur (Fig. 1, bottom). In both three- and four-strand branch migration, there is no net change in the number of hydrogen bonds. It is, therefore, an isoenergetic process and can occur spontaneously without the need for any exogenous energy source. More... »

PAGES

42-65

Book

TITLE

Nucleic Acids and Molecular Biology

ISBN

978-3-642-79490-2
978-3-642-79488-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-79488-9_3

DOI

http://dx.doi.org/10.1007/978-3-642-79488-9_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019971925


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