Investigational Therapy of Sepsis: Anti-TNF, IL-1ra, Anti-PAF and G-CSF View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1995

AUTHORS

J.-F. Dhainaut , J. P. Mira , F. Brunet

ABSTRACT

Severe sepsis and septic shock are widely recognized as serious clinical problems causing substantial morbidity and mortality [1], Despite modern antibiotics, state-of-the-art intensive care, and timely surgery, the sequelae of severe sepsis are seemingly dissociated in time from the underlying infection. Recent advances in the biology of inflammatory response to infection shed light on this apparent dissociation of tissue injury from the underlying infection [2]. Indeed, the host-derived factors of the inflammatory response that result in an effective defense against infection, may become exaggerated, causing severe sepsis and organ dysfunction syndrome [3–4]. These mediators of this response to infection could be ultimately responsible for the progression of the lethal sepsis. More... »

PAGES

267-282

Book

TITLE

Clinical Trials for the Treatment of Sepsis

ISBN

978-3-642-79226-7
978-3-642-79224-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-79224-3_17

DOI

http://dx.doi.org/10.1007/978-3-642-79224-3_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007553887


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