Genetic Alterations View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

M. Perucho , J. Schaeffer , A. Velazquez , G. Berrozpe , G. Capella

ABSTRACT

Pancreatic carcinoma is nearly always fatal, with a 5-year survival rate of 3%–5%. Although cigarette smoking is considered to be a risk factor, the etiology of this cancer is essentially unknown. The hypothesis that accumulative genetic alterations underlie the multistage process of tumorigenesis is becoming increasingly accepted. Mutations activate the malignant potential of oncogenes and inactivate the repressor function of tumor suppressor genes (reviewed in Bishop 1991). The paradigmatic examples of these genes are the ras oncogenes and the P53 tumor suppressor gene. More... »

PAGES

226-237

Book

TITLE

Facing the Pancreatic Dilemma

ISBN

978-3-540-58284-7
978-3-642-79167-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-79167-3_26

DOI

http://dx.doi.org/10.1007/978-3-642-79167-3_26

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016687862


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