The Effects of UV-B Radiation on the Mammalian Immune System View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

Edward C. DeFabo , Frances P. Noonan

ABSTRACT

Photoimmunology is the study of UV light and its effects on the mammalian immune system. UV light in this context is defined as radiation with wavelengths between 250 and 320 nm. These wavelengths describe part of the UV-C (200–280 nm) and all of the UV-A (280–320) waveband ranges. The effects of this radiation on immunity include suppression of the contact hypersensitivity response (CHS), an immune response similar to a poison ivy reaction, and suppression of the rejection of transplanted UV-induced skin tumors, a reaction directly involved in the outgrowth of skin cancer. Some evidence also exists that suggests that certain infectious diseases may be affected by UV immune suppression.To understand the basic mechanism involved, a variety of experiments have been employed including the identification of the active waveband emitted from experimental sunlamps, detailed dose-response analyses, the identification of the initial light absorber, or the photoreceptor to determine the process responsible for initiating the steps leading to systemic immune suppression and the involvement of antigen-specific T suppressor cells. These experiments will be summarized and a working hypothesis presented detailing what we postulate to be some of the major steps leading to immune suppression. The practical as well as the evolutionary advantages of such an unusual sunlight-activated immune-regulating mechanism on mammalian skin will be discussed. More... »

PAGES

349-349

Book

TITLE

Stratospheric Ozone Depletion/UV-B Radiation in the Biosphere

ISBN

978-3-642-78886-4
978-3-642-78884-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-78884-0_51

DOI

http://dx.doi.org/10.1007/978-3-642-78884-0_51

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026711378


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