Structure and Function of T4 Endonuclease V View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

S. Iwai , E. Ohtsuka

ABSTRACT

Ultraviolet (UV) light causes photolesions in DNA that induce genetic mutations (Friedberg 1985; Hutchinson 1987; Sage 1993). One of the well-characterized photolesions is cyclobutane pyrimidine dimers, which are produced by irradiation at wavelengths close to the absorption maximum of DNA (about 260 nm). This photoproduct has a cyclobutane ring formed by covalent bonds at the C5 and C6 positions between two adjacent pyrimidine bases, and the major isomer in DNA duplexes in cis-syn (Scheme 1). This type of lesion has been reported to induce mutations in vivo (Jiang and Taylor 1993; Kamiya et al. 1993). UV irradiation predominantly induces transitions from cytosine to thymine at sequences of adjacent pyrimidines (Miller 1985; Schaaper et al. 1987; Jiang and Taylor 1993). In our study, however, transversions from thymine to adenine occurred most frequently on the 3′-side of the cis-syn thymine dimer or on the 5′-side of the trans-syn thymine dimer, and these mutations in the ras oncogene induced focus-formation of NIH3T3 cells (Kamiya et al. 1993). More... »

PAGES

217-226

Book

TITLE

Nucleic Acids and Molecular Biology

ISBN

978-3-642-78668-6
978-3-642-78666-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-78666-2_12

DOI

http://dx.doi.org/10.1007/978-3-642-78666-2_12

DIMENSIONS

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