In Situ Expression of Cytokines in Renal Cell Carcinoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

C. Krüger , I. L. Noronha , H. Stein , R. Waldherr

ABSTRACT

Cytokines play an important role in the induction and maintenance of specific and nonspecific defense mechanisms by immunocompetent mononuclear cells in malignant tumors, including renal cell carcinoma (RCC) [1, 2]. Cytokines can directly or indirectly influence tumor cell growth and differentiation and are capable of influencing the expression of cell-surface antigens. While examining a series of RCC patients (n = 20) by means of immunocytochemistry with a polyclonal antibody to interleukin 6 (IL-6), we constantly observed positive reactions to IL-6 in tumor cells. Similar findings have been reported by other investigators in vitro [5, 8]. It has been suggested that IL-6 functions as an autocrine growth factor in RCC. Furthermore, in vitro experiments have shown that interleukin 4 alone or combined with interferon-γ (INF-γ) or tumor necrosis factor-α (TNF-α) inhibits tumor cell growth and modulates the expression of MHC class I and II antigens in RCC cells [6]. At present, however, only little information is available with respect to the expression of cytokines in RCC in situ. Therefore in a preliminary study we have analyzed the expression of selected cytokines and growth factors in a series of RCC patients by means of immunocytochemistry and molecular biology techniques. More... »

PAGES

104-111

Book

TITLE

Contemporary Research on Renal Cell Carcinoma

ISBN

978-3-642-78611-2
978-3-642-78609-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-78609-9_13

DOI

http://dx.doi.org/10.1007/978-3-642-78609-9_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049222636


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