Frequency of Aberrant Surface Marker Expression in 221 Cases of Adult Acute Leukemia: An Immunologic/Cytogenetic Analysis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

C. Tirier , R. Becher , W. Heit

ABSTRACT

Immunophenotyping of blast cells in acute leukemias with monoclonal antibodies became a routine diagnostic tool in the 1980s. Leukemias were defined similar to their normal progenitor counterpart according to the mosaic of antigens expressed in the various stages of differentiation during normal cell maturation [1]. In acute lymphoblastic leukemia, successful therapeutic strategies were designed in relation to the immunophenotype of blast cells [2,3]. Investigators soon described a group of leukemias who did not follow the normal pathway of differentiation but expressed aberrant antigens [4,5]. These leukemias were generally described as acute mixed lineage leukemias, acute hybrid leukemias, leukemias with lineage promiscuity [6,7]. More... »

PAGES

96-101

Book

TITLE

Acute Leukemias IV

ISBN

978-3-642-78352-4
978-3-642-78350-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-78350-0_17

DOI

http://dx.doi.org/10.1007/978-3-642-78350-0_17

DIMENSIONS

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