Hexamethypropylene Amine Oxime Single-Photon Emission-Computed Tomography in Perinatal Asphyxia and Ischemic—Hemorrhagic Lesions View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

J. Haddad , A. Constantinesco , A. Facello , B. Brunot , J. Messer

ABSTRACT

Perinatal asphyxia is a principal recognized cause of perinatal death and abnormal neurodevelopmental outcome in both mature and preterm neonates. Ischemia and hemorrhage are the main components of central nervous system (CNS) injuries following perinatal asphyxia. The initiating stimulus which leads to lesions is a lack of cerebral blood flow (CBF) autoregulation (Volpe 1987; Lou et al. 1979a). Besides conventional brain imaging, such as ultrasound (US), magnetic resonance imaging (MRI), or computed tomography (CT) scan, the assessment of cerebral hemodynamics seems to be interesting since CBF impairment constitutes the background of ischemia and hemorrhage. In the last few years, increasing interest has been focused on techniques using radionuclides to image and measure CBF. Among them, single photon emission computed tomography (SPECT) is far less expensive and not as complicated as the others (e.g., positron emission tomography-PET scan). Moreover, it has proven to be useful in evaluating cerebral perfusion (CP) or regional cerebral blood flow (rCBF) in adults and children (Hellman et al. 1990; Uvebrant et al. 1991). In neonates, few data are available (Denays et al. 1989; Haddad et al. 1991). In this chapter, we will give an overview of the use of SPECT based on our experience. At the moment we are investigating more than 45 neonates using this technique, mainly for anoxic-ischemic brain injuries. More... »

PAGES

206-225

Book

TITLE

Perinatal Asphyxia

ISBN

978-3-642-77898-8
978-3-642-77896-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-77896-4_16

DOI

http://dx.doi.org/10.1007/978-3-642-77896-4_16

DIMENSIONS

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