Circulating Tumour Necrosis Factor in Active Inflammatory Bowel Disease View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

K. R. Gardiner , M. I. Halliday , F. Lloyd , S. Stephens , B. J. Rowlands

ABSTRACT

Enteric bacteria and their products (endotoxins) have attracted attention as luminal antigens that may initiate or contribute to the enterocolitis and associated systemic illness of inflammatory bowel disease (IBD). It has been proposed that endotoxins originating from these intestinal flora cross the disrupted intestinal mucosal barrier of patients with IBD to enter the portal circulation [1]. If the hepatic capacity to eliminate endotoxins is exceeded, spillover into the systemic circulation occurs (Fig. 1). Systemic endotoxaemia has been demonstrated in ulcerative colitis and Crohn’s disease and shown to correlate positively with disease activity [1, 2]. More... »

PAGES

699-703

Book

TITLE

Host Defense Dysfunction in Trauma, Shock and Sepsis

ISBN

978-3-642-77407-2
978-3-642-77405-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-77405-8_90

DOI

http://dx.doi.org/10.1007/978-3-642-77405-8_90

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043091377


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