Idiotypic Regulation in Experimental Autoimmune Thyroiditis (EAT) View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1992

AUTHORS

H. Tang , C. Bédin , B. Texier , J. Charreire

ABSTRACT

The expression of antibody (Ab) idiotypes (id) by T lymphocytes has been long described in functional assays (Binz et al., 1976; Eichmann et al., 1978; Coutinho amp; Meo, 1983) and has been taken to suggest VH gene expression in both T and B lymphocytes. When T cell receptor (TCR) proteins (Allison et al., 1982; Meuer et al., 1983) and structural genes (Hedrick et al., 1984; Saito et al., 1984) were identified, the expression of Ab idiotopes by T lymphocytes was reinterpreted as resulting from powerful mechanisms occurring during the somatic selection of TCR on the basis of ids from Abs. Consequently, a functional idiotypic network was supposed to be responsible for this expression (Pereira et al., 1989). Simultaneously, experiments (Ertl et al., 1982; Sikora amp; Levy, 1980; Sikora et al., 1982; Singhai amp; Levy, 1987; Martinez-A. et al., 1987a, 1987b) were reported, describing such phenomenon. However, two of the investigators considered that they were aleatory expressions of T cell ids (Martinez-A. et al., 1987a, 1987b). More... »

PAGES

397-408

Book

TITLE

Theoretical and Experimental Insights into Immunology

ISBN

978-3-642-76979-5
978-3-642-76977-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-76977-1_26

DOI

http://dx.doi.org/10.1007/978-3-642-76977-1_26

DIMENSIONS

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