Strongest Relative Risk for Goitrous Hashimoto’s Thyroiditis Conferred by HLA-DQB1 Gene Variation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1991

AUTHORS

K. Badenhoop , G. Schwarz , P. G. Walfish , K. H. Usadel , G. F. Bottazzo

ABSTRACT

Hashimoto’s thyroiditis can be found in two forms: the goitrous and the atrophic variants. It is considered to be of autoimmune aetiology closely related to Graves’ disease. Both diseases can be observed clustered in families [1]. Furthermore, some patients progress from Graves’ disease to Hashimoto’s thyroiditis, illustrating that both diseases are part of one spectrum of thyroid autoimmunity. Antibodies to microsomal antigen (thyroid peroxidase) [2] and to thyroglobulin are detected, as well as occasionally antibodies to epitopes of the TSH receptor. Thyroid autoantibodies can also be found in relatives of patients with insulin-dependent diabetes mellitus (IDDM); these relatives show an association with the HLA specificity DR5 [3]. The disease itself has been shown to be associated with the HLA specificity DR5 in its hypertrophic form, with DR3 in its atrophic form and also with DR4 (reviewed in [4]). More... »

PAGES

29-39

References to SciGraph publications

Book

TITLE

Autoimmune Thyroiditis

ISBN

978-3-540-53476-1
978-3-642-76301-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-76301-4_4

DOI

http://dx.doi.org/10.1007/978-3-642-76301-4_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029284138


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