rIL-2 Immunotherapy for 19 Children with Advanced Metastatic Neuroblastoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

M. C. Favrot , J. Michon , E. Bouffet , S. Négrier , P. Cochat , D. Floret , M. Gaspard , C. Coze , G. Andreu , C. R. Franks , I. Philip , T. Philip

ABSTRACT

Considerable progress has been achieved in the treatment of stage IV neuroblastoma in children over 1 year of age. Induction therapy and surgery followed by vincristine, high-dose melphalan, total body irridiation, and autologous bone marrow transplantation (ABMT) enable the achievement of 40% progression-free survival at 2 years post-transplantation [1]. However, late relapses occurring up to 72 months post-graft, with a projected disease- free survival at 5 years of only 20% to 25%, are a major concern. Therefore, new therapeutic approaches are needed; spontaneous regression of this tumor in children below 1 year of age favors a role of the immune system in antitumoral defense and the potential benefit of immunotherapy. However, since neuroblastoma cells lack class I and II major histocompatibility complex (MHC) antigens, any attempt to stimulate antitumoral defense should involve non-MHC-restricted immunity. This work was supported by grant n°6245 from the Association pour la Recherche sur le Cancer, réseau INSERM LMCE n°48–60-22, and Comite de la Savoie of the Ligue Nationale contre le Cancer (grant RS-01()88). More... »

PAGES

683-690

Book

TITLE

Cytokines in Hemopoiesis, Oncology, and AIDS

ISBN

978-3-540-52281-2
978-3-642-75510-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-75510-1_86

DOI

http://dx.doi.org/10.1007/978-3-642-75510-1_86

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016026004


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