Ontology type: schema:Chapter
1991
AUTHORS ABSTRACTHistorically the discovery of this signalling system draws upon the convergence of two areas of research. The first was directed at the phenomenon of agonist induced inositol lipid turnover (reviewed in (Hokin, 1985)); the second was directed at the discovery and characterization of protein kinases with signalling potential, which lead to the identification of a calcium and phospholipid-dependent protein kinase termed protein kinase C (PKC) (see (Nishizuka, 1986; Nishizuka, 1988)). The critical link between these fields is the now established second messenger diacyglycerol (DAG) which is produced during agonist stimulated inositol lipid hydrolysis (by an inositol lipid-specific phospholipase C — Ptdlns- PLC) and is itself responsible for the activation of PKC (figure 1). The inositol 1,4,5 trisphosphate head group which is concurrently produced on degradation of Ptdlns 4,5 bisphosphate also serves a second messenger role in the release of Ca2+ from intracellular stores (Streb et. al., 1983). That DAG leads to PKC activation in vivo is evidenced by a variety of reports that short chain membrane permeable DAGs can activate PKC in intact cells as judged by the phosphorylation of particular proteins (e.g. (Kawahara et. al., 1980)). Furthermore such proteins can become phosphorylated in response to agonists that stimulate Ptdlns breakdown providing evidence for a causal role in the events of agonist induced cellular responses. More... »
PAGES167-177
Cellular Regulation by Protein Phosphorylation
ISBN
978-3-642-75144-8
978-3-642-75142-4
http://scigraph.springernature.com/pub.10.1007/978-3-642-75142-4_21
DOIhttp://dx.doi.org/10.1007/978-3-642-75142-4_21
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1038655494
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Cancer Research UK",
"id": "https://www.grid.ac/institutes/grid.11485.39",
"name": [
"Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln\u2019s Inn Fields, London, WC2A 3PX, England"
],
"type": "Organization"
},
"familyName": "Parker",
"givenName": "P. J.",
"id": "sg:person.01111564441.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1073/pnas.86.9.3099",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001266480"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-291x(79)91197-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003188531"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-5793(89)80160-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006566134"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.bi.54.070185.001225",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012020337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-291x(80)80169-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013637442"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.87.21.8622",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015617085"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1990.tb19431.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028525847"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.86.5.1568",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029825633"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1990.tb19472.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031112170"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(89)90048-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036180395"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.84.13.4418",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036867400"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0304-4157(85)90009-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039783225"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0304-4157(85)90009-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039783225"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/334661a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040491061",
"https://doi.org/10.1038/334661a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1988.tb13991.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041206967"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0167-4889(91)90177-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041929455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0167-4889(91)90177-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041929455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1989.tb14809.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042521739"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/306067a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045175878",
"https://doi.org/10.1038/306067a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-5793(90)80831-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046197121"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.86.13.4868",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051428882"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0303-7207(89)90159-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052228232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0303-7207(89)90159-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052228232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.2457254",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062538427"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.2541501",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062543191"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.3014651",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062582855"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078438055",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078771994",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078998880",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079020581",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079323687",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079586993",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079592449",
"type": "CreativeWork"
}
],
"datePublished": "1991",
"datePublishedReg": "1991-01-01",
"description": "Historically the discovery of this signalling system draws upon the convergence of two areas of research. The first was directed at the phenomenon of agonist induced inositol lipid turnover (reviewed in (Hokin, 1985)); the second was directed at the discovery and characterization of protein kinases with signalling potential, which lead to the identification of a calcium and phospholipid-dependent protein kinase termed protein kinase C (PKC) (see (Nishizuka, 1986; Nishizuka, 1988)). The critical link between these fields is the now established second messenger diacyglycerol (DAG) which is produced during agonist stimulated inositol lipid hydrolysis (by an inositol lipid-specific phospholipase C \u2014 Ptdlns- PLC) and is itself responsible for the activation of PKC (figure 1). The inositol 1,4,5 trisphosphate head group which is concurrently produced on degradation of Ptdlns 4,5 bisphosphate also serves a second messenger role in the release of Ca2+ from intracellular stores (Streb et. al., 1983). That DAG leads to PKC activation in vivo is evidenced by a variety of reports that short chain membrane permeable DAGs can activate PKC in intact cells as judged by the phosphorylation of particular proteins (e.g. (Kawahara et. al., 1980)). Furthermore such proteins can become phosphorylated in response to agonists that stimulate Ptdlns breakdown providing evidence for a causal role in the events of agonist induced cellular responses.",
"editor": [
{
"familyName": "Heilmeyer",
"givenName": "Ludwig M. G.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-3-642-75142-4_21",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-3-642-75144-8",
"978-3-642-75142-4"
],
"name": "Cellular Regulation by Protein Phosphorylation",
"type": "Book"
},
"name": "A Diversity of Elements in the Protein Kinase C Signal Transduction Pathway",
"pagination": "167-177",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-3-642-75142-4_21"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b8232f54c273084aeab4ffd8a98ddefef9b70b3309de805a4de89909eccbfd93"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1038655494"
]
}
],
"publisher": {
"location": "Berlin, Heidelberg",
"name": "Springer Berlin Heidelberg",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-3-642-75142-4_21",
"https://app.dimensions.ai/details/publication/pub.1038655494"
],
"sdDataset": "chapters",
"sdDatePublished": "2019-04-15T19:11",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000267.jsonl",
"type": "Chapter",
"url": "http://link.springer.com/10.1007/978-3-642-75142-4_21"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-75142-4_21'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-75142-4_21'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-75142-4_21'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-75142-4_21'
This table displays all metadata directly associated to this object as RDF triples.
150 TRIPLES
23 PREDICATES
57 URIs
20 LITERALS
8 BLANK NODES