Enhancement of Cytotoxic Efficacy of 5-Deoxy-5-fluorouridine in Acetoxymethyl-methylnitrosamine-Induced Colorectal Adenocarcinomas in SD Rats by Locoregional Administration into the Inferior Mesenteric ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

E. Petru , M. R. Berger , F. T. Garzon , D. Schmähl

ABSTRACT

Colorectal cancer is one of the most frequent tumors in the western world, with rising incidence and mortality [8]. Surgery remains the only modality with curative potential, but the majority of patients with advanced neoplasms are not amenable to surgical cure. Even when resection is possible, the patients remain at high risk for recurrence and metastasis. This situation leads to the concept of combined treatment, i.e., surgery with radiotherapy, which controls the locoregional recurrence, and/or chemotherapy, which in theory controls distant micrometastasis or systemic dissemination [4]. However, most patients with advanced disease experience progression in spite of conventional chemotherapy, which is characterized by being unspecific and displaying a narrow range between marginally active and toxic doses. More... »

PAGES

41-45

Book

TITLE

Progress in Regional Cancer Therapy

ISBN

978-3-642-74820-2
978-3-642-74818-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-74818-9_8

DOI

http://dx.doi.org/10.1007/978-3-642-74818-9_8

DIMENSIONS

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