1989
AUTHORSB. K. Keppler , M. Henn , U. M. Juhl , M. R. Berger , R. Niebl , F. E. Wagner
ABSTRACTThe aim of developing new tumor-inhibiting ruthenium complexes, in particular compounds which act against tumors that have been chemoresistant up to now, has led us to the synthesis of different classes of ruthenium complexes. These were selected for further evaluation on the basis of increase in survival time in the P388 tumor model and water-solubility. The water-soluble ruthenium complexes coordinated with heterocycle ligands intrans-position, HB(RuB2Cl4), and the corresponding pentachloro derivatives, (HB)2(RuBCl5), were identified as being the most active ones. Their chemical properties were investigated by means of x-ray analyses, Mössbauer spectra, NMR spectra, and other methods. Their galenic formulation was relatively easy to establish owing to their solubility in water or in physiological saline. Stability of the complexes turned out to be sufficient for infusion therapy. Antitumor activity of such compounds was confirmed not only in the P388 tumor model but also in the Walker 256 carcinosarcoma, the Stockholm Ascitic tumor, the subcutaneously growing B 16 melanoma, the intramusculary growing sarcoma 180 and the AMMN-induced colorectal tumors of the rat. More... »
PAGES41-69
Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy
ISBN
978-3-642-74762-5
978-3-642-74760-1
http://scigraph.springernature.com/pub.10.1007/978-3-642-74760-1_3
DOIhttp://dx.doi.org/10.1007/978-3-642-74760-1_3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1000987926
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Anorganisch-Chemisches Institut der Universit\u00e4t Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7700.0",
"name": [
"Anorganisch-Chemisches Institut der Universit\u00e4t Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Keppler",
"givenName": "B. K.",
"id": "sg:person.012522751162.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012522751162.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Anorganisch-Chemisches Institut der Universit\u00e4t Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7700.0",
"name": [
"Anorganisch-Chemisches Institut der Universit\u00e4t Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Henn",
"givenName": "M.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Anorganisch-Chemisches Institut der Universit\u00e4t Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7700.0",
"name": [
"Anorganisch-Chemisches Institut der Universit\u00e4t Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Juhl",
"givenName": "U. M.",
"id": "sg:person.012571514275.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012571514275.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut f\u00fcr Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Institut f\u00fcr Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Berger",
"givenName": "M. R.",
"id": "sg:person.01256203524.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203524.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Anorganisch-Chemisches Institut der Universit\u00e4t Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany",
"id": "http://www.grid.ac/institutes/grid.7700.0",
"name": [
"Anorganisch-Chemisches Institut der Universit\u00e4t Heidelberg, Im Neuenheimer Feld 270, 6900, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Niebl",
"givenName": "R.",
"id": "sg:person.014032013225.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014032013225.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Physik-Department E15, Technische Universit\u00e4t M\u00fcnchen, 8046, Garching, Germany",
"id": "http://www.grid.ac/institutes/grid.6936.a",
"name": [
"Physik-Department E15, Technische Universit\u00e4t M\u00fcnchen, 8046, Garching, Germany"
],
"type": "Organization"
},
"familyName": "Wagner",
"givenName": "F. E.",
"type": "Person"
}
],
"datePublished": "1989",
"datePublishedReg": "1989-01-01",
"description": "The aim of developing new tumor-inhibiting ruthenium complexes, in particular compounds which act against tumors that have been chemoresistant up to now, has led us to the synthesis of different classes of ruthenium complexes. These were selected for further evaluation on the basis of increase in survival time in the P388 tumor model and water-solubility. The water-soluble ruthenium complexes coordinated with heterocycle ligands intrans-position, HB(RuB2Cl4), and the corresponding pentachloro derivatives, (HB)2(RuBCl5), were identified as being the most active ones. Their chemical properties were investigated by means of x-ray analyses, M\u00f6ssbauer spectra, NMR spectra, and other methods. Their galenic formulation was relatively easy to establish owing to their solubility in water or in physiological saline. Stability of the complexes turned out to be sufficient for infusion therapy. Antitumor activity of such compounds was confirmed not only in the P388 tumor model but also in the Walker 256 carcinosarcoma, the Stockholm Ascitic tumor, the subcutaneously growing B 16 melanoma, the intramusculary growing sarcoma 180 and the AMMN-induced colorectal tumors of the rat.",
"editor": [
{
"familyName": "Baulieu",
"givenName": "Etienne",
"type": "Person"
},
{
"familyName": "Forman",
"givenName": "Donald T.",
"type": "Person"
},
{
"familyName": "Ingelman-Sundberg",
"givenName": "Magnus",
"type": "Person"
},
{
"familyName": "Jaenicke",
"givenName": "Lothar",
"type": "Person"
},
{
"familyName": "Kellen",
"givenName": "John A.",
"type": "Person"
},
{
"familyName": "Nagai",
"givenName": "Yoshitaka",
"type": "Person"
},
{
"familyName": "Springer",
"givenName": "Georg F.",
"type": "Person"
},
{
"familyName": "Tr\u00e4ger",
"givenName": "Lothar",
"type": "Person"
},
{
"familyName": "Will-Shahab",
"givenName": "Liane",
"type": "Person"
},
{
"familyName": "Wittliff",
"givenName": "James L.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-3-642-74760-1_3",
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-3-642-74762-5",
"978-3-642-74760-1"
],
"name": "Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy",
"type": "Book"
},
"keywords": [
"ruthenium complexes",
"water-soluble ruthenium complexes",
"new ruthenium complexes",
"X-ray analysis",
"heterocycle ligand",
"NMR spectra",
"such compounds",
"chemical properties",
"particular compound",
"M\u00f6ssbauer spectra",
"complexes",
"pentachloro derivatives",
"compounds",
"active ones",
"treatment of cancer",
"spectra",
"antitumor activity",
"ligands",
"solubility",
"synthesis",
"derivatives",
"basis of increase",
"galenic formulation",
"stability",
"water",
"different classes",
"properties",
"sarcoma 180",
"Walker 256 carcinosarcoma",
"formulation",
"tumor model",
"activity",
"method",
"means",
"class",
"basis",
"analysis",
"physiological saline",
"increase",
"ascitic tumor",
"time",
"one",
"treatment",
"evaluation",
"AMMN",
"model",
"further evaluation",
"saline",
"aim",
"cancer",
"therapy",
"tumors",
"chemoresistant",
"rats",
"melanoma",
"colorectal tumors",
"survival time",
"carcinosarcoma",
"infusion therapy"
],
"name": "New Ruthenium Complexes for the Treatment of Cancer",
"pagination": "41-69",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1000987926"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-3-642-74760-1_3"
]
}
],
"publisher": {
"name": "Springer Nature",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-3-642-74760-1_3",
"https://app.dimensions.ai/details/publication/pub.1000987926"
],
"sdDataset": "chapters",
"sdDatePublished": "2022-08-04T17:15",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/chapter/chapter_196.jsonl",
"type": "Chapter",
"url": "https://doi.org/10.1007/978-3-642-74760-1_3"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-74760-1_3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-74760-1_3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-74760-1_3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-74760-1_3'
This table displays all metadata directly associated to this object as RDF triples.
202 TRIPLES
22 PREDICATES
84 URIs
77 LITERALS
7 BLANK NODES