1989
AUTHORSB. K. Keppler , M. Henn , U. M. Juhl , M. R. Berger , R. Niebl , F. E. Wagner
ABSTRACTThe aim of developing new tumor-inhibiting ruthenium complexes, in particular compounds which act against tumors that have been chemoresistant up to now, has led us to the synthesis of different classes of ruthenium complexes. These were selected for further evaluation on the basis of increase in survival time in the P388 tumor model and water-solubility. The water-soluble ruthenium complexes coordinated with heterocycle ligands intrans-position, HB(RuB2Cl4), and the corresponding pentachloro derivatives, (HB)2(RuBCl5), were identified as being the most active ones. Their chemical properties were investigated by means of x-ray analyses, Mössbauer spectra, NMR spectra, and other methods. Their galenic formulation was relatively easy to establish owing to their solubility in water or in physiological saline. Stability of the complexes turned out to be sufficient for infusion therapy. Antitumor activity of such compounds was confirmed not only in the P388 tumor model but also in the Walker 256 carcinosarcoma, the Stockholm Ascitic tumor, the subcutaneously growing B 16 melanoma, the intramusculary growing sarcoma 180 and the AMMN-induced colorectal tumors of the rat. More... »
PAGES41-69
Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy
ISBN
978-3-642-74762-5
978-3-642-74760-1
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DOIhttp://dx.doi.org/10.1007/978-3-642-74760-1_3
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