New Ruthenium Complexes for the Treatment of Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

B. K. Keppler , M. Henn , U. M. Juhl , M. R. Berger , R. Niebl , F. E. Wagner

ABSTRACT

The aim of developing new tumor-inhibiting ruthenium complexes, in particular compounds which act against tumors that have been chemoresistant up to now, has led us to the synthesis of different classes of ruthenium complexes. These were selected for further evaluation on the basis of increase in survival time in the P388 tumor model and water-solubility. The water-soluble ruthenium complexes coordinated with heterocycle ligands intrans-position, HB(RuB2Cl4), and the corresponding pentachloro derivatives, (HB)2(RuBCl5), were identified as being the most active ones. Their chemical properties were investigated by means of x-ray analyses, Mössbauer spectra, NMR spectra, and other methods. Their galenic formulation was relatively easy to establish owing to their solubility in water or in physiological saline. Stability of the complexes turned out to be sufficient for infusion therapy. Antitumor activity of such compounds was confirmed not only in the P388 tumor model but also in the Walker 256 carcinosarcoma, the Stockholm Ascitic tumor, the subcutaneously growing B 16 melanoma, the intramusculary growing sarcoma 180 and the AMMN-induced colorectal tumors of the rat. More... »

PAGES

41-69

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-74760-1_3

DOI

http://dx.doi.org/10.1007/978-3-642-74760-1_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000987926


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