Genetics of src: Structure and Functional Organization of a Protein Tyrosine Kinase View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

J. Thomas Parsons , Michael J. Weber

ABSTRACT

The observations of Peyton Rous almost 80 years ago provided the first clues to the viral etiology of cancer. Since that time the study of transforming retroviruses such as Rous sarcoma virus (RSV) and the subsequent identification of the genes responsible for the induction of the neoplastic state (oncogenes) have provided a foundation for understanding the molecular basis of cancer (Bishop 1987). Of equal importance is the recognition that transforming retroviruses transduce cellular gene sequences that encode proteins which function in the process of normal cell growth and differentiation. The analysis of transforming retroviruses therefore provides a unique opportunity to identify, isolate, and characterize cellular proteins that play fundamental roles in the regulation of normal and malignant cell growth. Genetic and biochemical studies using RSV have played a preeminent role in defining the relationship between virus expression and cellular transformation. Genetic evidence for a unique gene required for transformation was provided by Martin (1970), Kawai and Hanafusa (1971), and Toyoshima and Vogt (1969) with the isolation of temperature-sensitive mutants of RSV, thus clearly implicating a viral gene product in the transformation process. More... »

PAGES

79-127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-74697-0_3

DOI

http://dx.doi.org/10.1007/978-3-642-74697-0_3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043223591

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2482802


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