Regeneration of Granulopoiesis with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor After Bone Marrow Transplantation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

H. Link , J. Seidel , M. Stoll , H. Kirchner , C. Linderkamp , M. Freund , P. Bucsky , K. Welte , H. Riehm , S. Burdach , M. Hauch , B. Koci , G. Schulz , H. Poliwoda

ABSTRACT

In the period immediately following bone marrow transplantation, most patients contract infections which contribute significantly to morbidity and mortality. These infections during the granulocytopenic phase following pretreatment for BMT are more severe than during the granulocytopenia caused by conventional cytotoxic treatment. The higher doses of cytostatic drugs damage the defense mechanisms of the mechanical barriers such as skin and mucous membranes. The mucositis in the mouth and the entire gastrointestinal tract caused by cytostatic drugs and radiation can be superinfected by colonizing microflora, producing an initial focus for severe septic infections during granulocytopenia. More... »

PAGES

741-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-74643-7_136

DOI

http://dx.doi.org/10.1007/978-3-642-74643-7_136

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052460685

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2182465


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