Proposal for the Classification of Relapsed and Refractory Acute Myeloid Leukemias as the Basis for an Age-Adjusted Randomized Comparison of ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

W. Hiddemann , H. C. Aul , G. Maschmeyer , D. Urbanitz , B. Lathan , A. Reichle , H. Köppler , R. Donhuijsen-Ant , W. D. Ludwig , T. Grüneisen , P. Bettelheim , W. Schroyens , L. Balleisen , H. Bartels , C. Sauerland , A. Heinecke , T. Büchner

ABSTRACT

In spite of the substantial improvement of first-line treatment in adult patients with acute myeloid leukemia (AML) and a grad-ual increase in long-term remissions, the majority of patients still relapse with their disease and ultimately die due to drug-resistant leukemia. More effective antileukemic therapy is therefore warranted and a variety of new drugs or new applications and dose ranges of established agents have been explored in clinical phase I and II studies. From these investigations cytosine arabinoside (Ara-C) obviously emerged as the most active single agent when administered at doses between 1.0 and 3.0 g/m2 over 4–6 days [1–7]. A more detailed analysis, however, reveals a substantial interstudy variation of response rates ranging from 11% to 70% even when considering only studies using the original Herzig regimen of 12 single doses of 3.0 g/m2 high-dose (HD) Ara-C [1–8]. More... »

PAGES

604-609

Book

TITLE

Acute Leukemias II

ISBN

978-3-540-50984-4
978-3-642-74643-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-74643-7_110

DOI

http://dx.doi.org/10.1007/978-3-642-74643-7_110

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003548993

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2182450


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27 schema:description In spite of the substantial improvement of first-line treatment in adult patients with acute myeloid leukemia (AML) and a grad-ual increase in long-term remissions, the majority of patients still relapse with their disease and ultimately die due to drug-resistant leukemia. More effective antileukemic therapy is therefore warranted and a variety of new drugs or new applications and dose ranges of established agents have been explored in clinical phase I and II studies. From these investigations cytosine arabinoside (Ara-C) obviously emerged as the most active single agent when administered at doses between 1.0 and 3.0 g/m2 over 4–6 days [1–7]. A more detailed analysis, however, reveals a substantial interstudy variation of response rates ranging from 11% to 70% even when considering only studies using the original Herzig regimen of 12 single doses of 3.0 g/m2 high-dose (HD) Ara-C [1–8].
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40 applications
41 ara
42 arabinoside
43 basis
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