Tumor Cells Genetically Tagged with Transferred DNA Markers Reveal Evidence for Clonal Dominance of Primary Tumors by Metastatic Subpopulations View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1989

AUTHORS

R. S. Kerbel , C. Waghorne , B. Korczak , M. L. Breitman

ABSTRACT

Despite the evidence that neoplasms begin with the oncogenic transformation of a single normal cell they virtually always become genotypically and phenotypically heterogeneous by the time they are clinically detectable (Nowell 1976). This is thought to occur through the continuous emergence of new variant subclones as a result of random or induced genetic mutations combined with selection of the more aggressive of these new subpopulations (Nowell 1976). As a result, tumor progression can be viewed as a Darwinian-like microevolutionary process. There is evidence that variant cell subpopulations having competence for metastasis or manifesting certain kinds of drug resistance arise as a result of this process (Nowell 1976). With respect to the metastatic phenotype, a prediction of this model is that cells recovered from metastases would on average manifest a greater metastatic ability than tumor cells recovered from the corresponding primary tumor. This prediction was fulfilled, as first reported by Fidler (1973). As a result of this pioneering study it has become routine to compare cells of primary tumors and their metastases as a means of determining the cellular factors which govern expression of metastatic behavior. More... »

PAGES

21-26

Book

TITLE

Cancer Metastasis

ISBN

978-3-540-50471-9
978-3-642-74236-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-74236-1_3

DOI

http://dx.doi.org/10.1007/978-3-642-74236-1_3

DIMENSIONS

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