Insulin Regulation of Protein Phosphorylation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

J. Avruch , H. E. Tornqvist , J. R. Gunsalus , E. J. Yurkow , J. M. Kyriakis , D. J. Price

ABSTRACT

This chapter will consider the role of regulatory protein phosphorylation in the sequence of reactions intermediate between insulin binding at the cell surface, and the distal biologic effects. The major biologic actions and in vivo physiologic roles of insulin (at least in postnatal life) have been understood for some time (CAHILL 1971): as the primary hormone of energy storage in adult mammals, insulin’s dual physiologic roles are directed toward promoting nutrient entry and assimilation into macromolecules/storage forms (anabolism), as well as inhibiting the breakdown of these macromolecules/energy stores and their release into circulation for oxidation by tissues (anticatabolism). The changes in the cellular physiology of skeletal muscle, liver, and adipose tissue (CAHILL and STEINER 1972), which determine the integrated in vivo response have been well described. This situation is unique among hormones which act through receptor tyrosine kinases; the physiologic roles of these so-called growth factors in the intact organism are largely unknown, although plausible scenarios can be constructed for several, e.g., IGF-I and PDGF. It was anticipated that because the physiologically relevant molecular targets of insulin regulation could be clearly identified (e.g., glucose transport and the enzymes regulating glycogen, fatty acid, and triglyceride metabolism), the pertinent components of the intracellular signaling pathway, which couple the receptor tyrosine kinase to these targets, would also be most readily identified in the insulin system. Although this supposition may yet prove true, and progress has been steady (CZECH 1985; BELFRAGE et al. 1986 b; ROSEN 1987, GOREN et al. 1988), it is still not possible to enumerate the complete series of steps which couple insulin receptor activation to any of the distal biologic responses. More... »

PAGES

313-366

Book

TITLE

Insulin

ISBN

978-3-642-74100-5
978-3-642-74098-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-74098-5_15

DOI

http://dx.doi.org/10.1007/978-3-642-74098-5_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017848722


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