Induction and Maintenance of Long-Term Potentiation in the Hippocampus View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

T. V. P. Bliss , M. L. Errington , M. A. Lynch

ABSTRACT

There is increasing evidence to suggest that at least some types of learning are encoded in the mammalian brain by a form of synaptic plasticity that may be broadly described as Hebbian, in that underlying changes in synaptic strength occur as the result of coincident preand post-synaptic activity (Hebb, 1949; Singer, 1987; Ito, 1987). A widely-studied example of this sort of plasticity is the enduring enhancement of synaptic transmission known as long-term potentiation (LTP), which is produced with beguiling ease by the application of brief trains of high-frequency stimulation to any of the main excitatory pathways of the hippocampal formation (Bliss and Lomo, 1973; Teyler and DiScenna, 1987; Bliss and Lynch, 1988). In the last few years a concensus has developed regarding the cellular events leading to the initiation of LTP; in this view, LTP develops, in susceptible synapses, whenever there is a conjunction of synaptic activity and strong postsynaptic depolarization, conditions which allow the opening of the voltage-dependent ion channel associated with the NMDA subtype of glutamate receptor. A similar concensus on how the potentiated state is maintained has yet to emerge, with evidence for persistent changes in transmitter release and in synaptic morphology, possibly reflecting changes in protein phosphorylation, redistribution of calcium stores, and changes in protein synthesis. In this chapter we present a summary of the evidence which has led to our present understanding of the mechanisms responsible for the induction and maintenance of LTP. More... »

PAGES

213-225

References to SciGraph publications

  • 1977-04. Specific long-lasting potentiation of synaptic transmission in hippocampal slices in NATURE
  • 1977-04. Heterosynaptic depression: a postsynaptic correlate of long-term potentiation in NATURE
  • 1984-02. Magnesium gates glutamate-activated channels in mouse central neurones in NATURE
  • 1986-07. The long and the short of long–term memory—a molecular framework in NATURE
  • 1988. On the Mechanism of Increased Transmitter Release in LTP: Measurements of Calcium Concentration and Phosphatidylinositol Turnover in CA3 Synaptosomes in SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS
  • 1986-05. Potentiation of synaptic transmission in the hippocampus by phorbol esters in NATURE
  • 1987-07. Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation in NATURE
  • 1986-02. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5 in NATURE
  • 1982-06. Long-term potentiation of the perforant path in vivo is associated with increased glutamate release in NATURE
  • 1987-07. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells in NATURE
  • 1986-05. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones in NATURE
  • 1983-10. Intracellular injections of EGTA block induction of hippocampal long-term potentiation in NATURE
  • 1987-06. Postsynaptic long-term potentiation follows coupling of dendritic glutamate application and synaptic activation in CELLULAR AND MOLECULAR LIFE SCIENCES
  • Book

    TITLE

    Modulation of Synaptic Transmission and Plasticity in Nervous Systems

    ISBN

    978-3-642-73162-4
    978-3-642-73160-0

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-3-642-73160-0_16

    DOI

    http://dx.doi.org/10.1007/978-3-642-73160-0_16

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030016759


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