Phthalocyanines as Sensitizers for Photodynamic Therapy of Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

J. E. van Lier , N. Brasseur , B. Paquette , J. R. Wagner , H. Ali , R. Langlois , J. Rousseau

ABSTRACT

Photodynamic therapy (PDT) of neoplasms using photosensitizers and red light, is currently undergoing clinical trials throughout the world.1 The sensitizer preparation used almost exclusively in PDT consists of a mixture of hematoporphyrin derivatives (HPD) obtained from alkaline hydrolysis of hematoporphyrin acetates.2 The most active compounds in this mixture are believed to be dihematoporphyrin ethers3 and/or esters,4 known as DHE. A commercial preparation enriched in the latter (Photofrin IItm) has been made available for research and clinical trials by Photomedica Inc. The effectiveness of DHE in PDT results from two important properties: (a) selective retention by neoplasms, and (b) induction of cellular damage upon light excitation, most likely through 1O2 formation.5 Advantages of this procedure as compared to conventional cancer treatment modalities include selectivity and low systemic toxicity. A particular advantage of PDT is that it can be applied to recurrences in regions which have already received maximal doses of conventional radiotherapy. More... »

PAGES

435-444

Book

TITLE

Photosensitisation

ISBN

978-3-642-73153-2
978-3-642-73151-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-73151-8_63

DOI

http://dx.doi.org/10.1007/978-3-642-73151-8_63

DIMENSIONS

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41 schema:description Photodynamic therapy (PDT) of neoplasms using photosensitizers and red light, is currently undergoing clinical trials throughout the world.1 The sensitizer preparation used almost exclusively in PDT consists of a mixture of hematoporphyrin derivatives (HPD) obtained from alkaline hydrolysis of hematoporphyrin acetates.2 The most active compounds in this mixture are believed to be dihematoporphyrin ethers3 and/or esters,4 known as DHE. A commercial preparation enriched in the latter (Photofrin IItm) has been made available for research and clinical trials by Photomedica Inc. The effectiveness of DHE in PDT results from two important properties: (a) selective retention by neoplasms, and (b) induction of cellular damage upon light excitation, most likely through 1O2 formation.5 Advantages of this procedure as compared to conventional cancer treatment modalities include selectivity and low systemic toxicity. A particular advantage of PDT is that it can be applied to recurrences in regions which have already received maximal doses of conventional radiotherapy.
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