Human Follicular Lymphomas: Identification of a Second t(14;18) Breakpoint Cluster Region View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1987

AUTHORS

N. Galili , M. L. Cleary , J. Sklar

ABSTRACT

Most follicular lymphomas, which comprise nearly two-thirds of the non-Hodgkin’s lymphomas occurring in U.S. adults, have been shown by cytogenetic analyses to contain a t(14;18) translocation [1, 2]. This breakpoint on chromosome 14 has been localized to band 14q32, the site of the immunoglobulin heavy chain genes. It was thus possible to use human Ig gene fragments to clone out a breakpoint DNA fragment (pFL-1) from tissue biopsy specimens of these lymphomas and from cell lines containing this translocation. When used as a hybridization probe, rearranged pFL-1 containing DNA was detected in approximately 60% of follicular lymphomas. Thus, a significant percentage of follicular lymphomas failed to show a breakpoint on chromosome 18 within 15–20 kb on either side of the breakpoint region. We describe here the cloning of a chromosome 18 DNA fragment (pFL-2) that detects t(14;18) rearranged DNA in most of these negative follicular lymphomas. More... »

PAGES

167-71

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-72624-8_36

DOI

http://dx.doi.org/10.1007/978-3-642-72624-8_36

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028513299

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3443390


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 14", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Translocation, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Laboratory of Experimental Oncology, Department of Pathology, Stanford University, Stanford, California\u00a094305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galili", 
        "givenName": "N.", 
        "id": "sg:person.01125345436.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125345436.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Laboratory of Experimental Oncology, Department of Pathology, Stanford University, Stanford, California\u00a094305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cleary", 
        "givenName": "M. L.", 
        "id": "sg:person.013764547412.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013764547412.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Laboratory of Experimental Oncology, Department of Pathology, Stanford University, Stanford, California\u00a094305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sklar", 
        "givenName": "J.", 
        "id": "sg:person.0621216003.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621216003.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0092-8674(85)80070-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001046047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(83)90040-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006623788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(83)90040-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006623788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01534738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017412972", 
          "https://doi.org/10.1007/bf01534738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.74.12.5463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025360556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198211113072002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036959456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.82.21.7439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047611732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3929382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062622560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6093263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062634110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081364954", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1987", 
    "datePublishedReg": "1987-01-01", 
    "description": "Most follicular lymphomas, which comprise nearly two-thirds of the non-Hodgkin\u2019s lymphomas occurring in U.S. adults, have been shown by cytogenetic analyses to contain a t(14;18) translocation [1, 2]. This breakpoint on chromosome 14 has been localized to band 14q32, the site of the immunoglobulin heavy chain genes. It was thus possible to use human Ig gene fragments to clone out a breakpoint DNA fragment (pFL-1) from tissue biopsy specimens of these lymphomas and from cell lines containing this translocation. When used as a hybridization probe, rearranged pFL-1 containing DNA was detected in approximately 60% of follicular lymphomas. Thus, a significant percentage of follicular lymphomas failed to show a breakpoint on chromosome 18 within 15\u201320 kb on either side of the breakpoint region. We describe here the cloning of a chromosome 18 DNA fragment (pFL-2) that detects t(14;18) rearranged DNA in most of these negative follicular lymphomas.", 
    "editor": [
      {
        "familyName": "Neth", 
        "givenName": "Rolf", 
        "type": "Person"
      }, 
      {
        "familyName": "Gallo", 
        "givenName": "Robert C.", 
        "type": "Person"
      }, 
      {
        "familyName": "Greaves", 
        "givenName": "Melvyn F.", 
        "type": "Person"
      }, 
      {
        "familyName": "Kabisch", 
        "givenName": "Hartmut", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-3-642-72624-8_36", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-3-540-17754-8", 
        "978-3-642-72624-8"
      ], 
      "name": "Modern Trends in Human Leukemia VII", 
      "type": "Book"
    }, 
    "name": "Human Follicular Lymphomas: Identification of a Second t(14;18) Breakpoint Cluster Region", 
    "pagination": "167-71", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-3-642-72624-8_36"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "87d43d471e90fbf872b28f4e5502bf9431d96341df288470b86434cd18437d4d"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028513299"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3443390"
        ]
      }
    ], 
    "publisher": {
      "location": "Berlin, Heidelberg", 
      "name": "Springer Berlin Heidelberg", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-3-642-72624-8_36", 
      "https://app.dimensions.ai/details/publication/pub.1028513299"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T18:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000260.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-3-642-72624-8_36"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-72624-8_36'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-72624-8_36'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-72624-8_36'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-3-642-72624-8_36'


 

This table displays all metadata directly associated to this object as RDF triples.

161 TRIPLES      23 PREDICATES      46 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-3-642-72624-8_36 schema:about N406c29f65e8842e1813109e74c761922
2 N458790d9213a4fc8a5a05a07fa9cb8f5
3 N5274a9c2d5314a07a330b837231446b7
4 Nae3fb622f868435aa15b2d1d5048cabe
5 Nc0554d00f1d445b88ea26cd7b42c94fd
6 Nd55493ef759a4f99a74c523afa8ff33e
7 Nd6a30b18b72b41c39bf250fb8c8947c6
8 Neb4b521737b9437eb4ad5eb3e588e23e
9 Nfa10548f592441a684626970406ee376
10 anzsrc-for:06
11 anzsrc-for:0604
12 schema:author N2e40b9a97d604fc08bce689e2dc324da
13 schema:citation sg:pub.10.1007/bf01534738
14 https://app.dimensions.ai/details/publication/pub.1081364954
15 https://doi.org/10.1016/0378-1119(83)90040-9
16 https://doi.org/10.1016/s0092-8674(85)80070-2
17 https://doi.org/10.1056/nejm198211113072002
18 https://doi.org/10.1073/pnas.74.12.5463
19 https://doi.org/10.1073/pnas.82.21.7439
20 https://doi.org/10.1126/science.3929382
21 https://doi.org/10.1126/science.6093263
22 schema:datePublished 1987
23 schema:datePublishedReg 1987-01-01
24 schema:description Most follicular lymphomas, which comprise nearly two-thirds of the non-Hodgkin’s lymphomas occurring in U.S. adults, have been shown by cytogenetic analyses to contain a t(14;18) translocation [1, 2]. This breakpoint on chromosome 14 has been localized to band 14q32, the site of the immunoglobulin heavy chain genes. It was thus possible to use human Ig gene fragments to clone out a breakpoint DNA fragment (pFL-1) from tissue biopsy specimens of these lymphomas and from cell lines containing this translocation. When used as a hybridization probe, rearranged pFL-1 containing DNA was detected in approximately 60% of follicular lymphomas. Thus, a significant percentage of follicular lymphomas failed to show a breakpoint on chromosome 18 within 15–20 kb on either side of the breakpoint region. We describe here the cloning of a chromosome 18 DNA fragment (pFL-2) that detects t(14;18) rearranged DNA in most of these negative follicular lymphomas.
25 schema:editor Na5d4df96f073479f90867bcfc6403ad9
26 schema:genre chapter
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N5a8fdd2f53e5465b9f56573ec1750678
30 schema:name Human Follicular Lymphomas: Identification of a Second t(14;18) Breakpoint Cluster Region
31 schema:pagination 167-71
32 schema:productId N197a63831fb1430d829e4e48ca03a696
33 N31524bd979d64c7a9a4078e092bad166
34 Na9ea74b6a4194952b8f33e21266c50bc
35 Nd23157b8116c4c499205cf4c202c49d1
36 schema:publisher N0496b58e499f414d9eba8de924ed4cdb
37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028513299
38 https://doi.org/10.1007/978-3-642-72624-8_36
39 schema:sdDatePublished 2019-04-15T18:11
40 schema:sdLicense https://scigraph.springernature.com/explorer/license/
41 schema:sdPublisher Ne970021e051a4ddf80b31b60afc93276
42 schema:url http://link.springer.com/10.1007/978-3-642-72624-8_36
43 sgo:license sg:explorer/license/
44 sgo:sdDataset chapters
45 rdf:type schema:Chapter
46 N0496b58e499f414d9eba8de924ed4cdb schema:location Berlin, Heidelberg
47 schema:name Springer Berlin Heidelberg
48 rdf:type schema:Organisation
49 N197a63831fb1430d829e4e48ca03a696 schema:name pubmed_id
50 schema:value 3443390
51 rdf:type schema:PropertyValue
52 N1f8373293de34afa85e9d8803d091039 rdf:first N742251a6d7af4bf688c064bb02dc2108
53 rdf:rest N96bc4a62f2f54373af66ef72e465e1bd
54 N2046423ff26847a795fb1b3753163d40 rdf:first sg:person.0621216003.23
55 rdf:rest rdf:nil
56 N2e40b9a97d604fc08bce689e2dc324da rdf:first sg:person.01125345436.28
57 rdf:rest Nfb8650a592084e9fa6b78abae0f41558
58 N31524bd979d64c7a9a4078e092bad166 schema:name readcube_id
59 schema:value 87d43d471e90fbf872b28f4e5502bf9431d96341df288470b86434cd18437d4d
60 rdf:type schema:PropertyValue
61 N33c3cdfacf954c8e8cf0ed805f931a9e schema:familyName Kabisch
62 schema:givenName Hartmut
63 rdf:type schema:Person
64 N384a8feab5ad48caa6826e3405b0f464 rdf:first Na35151c095b34a4dba200328c5f18ec5
65 rdf:rest N1f8373293de34afa85e9d8803d091039
66 N406c29f65e8842e1813109e74c761922 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Molecular Sequence Data
68 rdf:type schema:DefinedTerm
69 N458790d9213a4fc8a5a05a07fa9cb8f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Lymphoma
71 rdf:type schema:DefinedTerm
72 N5274a9c2d5314a07a330b837231446b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Cloning, Molecular
74 rdf:type schema:DefinedTerm
75 N5a8fdd2f53e5465b9f56573ec1750678 schema:isbn 978-3-540-17754-8
76 978-3-642-72624-8
77 schema:name Modern Trends in Human Leukemia VII
78 rdf:type schema:Book
79 N742251a6d7af4bf688c064bb02dc2108 schema:familyName Greaves
80 schema:givenName Melvyn F.
81 rdf:type schema:Person
82 N96bc4a62f2f54373af66ef72e465e1bd rdf:first N33c3cdfacf954c8e8cf0ed805f931a9e
83 rdf:rest rdf:nil
84 Na35151c095b34a4dba200328c5f18ec5 schema:familyName Gallo
85 schema:givenName Robert C.
86 rdf:type schema:Person
87 Na5d4df96f073479f90867bcfc6403ad9 rdf:first Ne5462c19962e491082ff3eeaccb7b1c7
88 rdf:rest N384a8feab5ad48caa6826e3405b0f464
89 Na9ea74b6a4194952b8f33e21266c50bc schema:name dimensions_id
90 schema:value pub.1028513299
91 rdf:type schema:PropertyValue
92 Nae3fb622f868435aa15b2d1d5048cabe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Humans
94 rdf:type schema:DefinedTerm
95 Nc0554d00f1d445b88ea26cd7b42c94fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Chromosomes, Human, Pair 18
97 rdf:type schema:DefinedTerm
98 Nd23157b8116c4c499205cf4c202c49d1 schema:name doi
99 schema:value 10.1007/978-3-642-72624-8_36
100 rdf:type schema:PropertyValue
101 Nd55493ef759a4f99a74c523afa8ff33e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name DNA, Neoplasm
103 rdf:type schema:DefinedTerm
104 Nd6a30b18b72b41c39bf250fb8c8947c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Base Sequence
106 rdf:type schema:DefinedTerm
107 Ne5462c19962e491082ff3eeaccb7b1c7 schema:familyName Neth
108 schema:givenName Rolf
109 rdf:type schema:Person
110 Ne970021e051a4ddf80b31b60afc93276 schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 Neb4b521737b9437eb4ad5eb3e588e23e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Chromosomes, Human, Pair 14
114 rdf:type schema:DefinedTerm
115 Nfa10548f592441a684626970406ee376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Translocation, Genetic
117 rdf:type schema:DefinedTerm
118 Nfb8650a592084e9fa6b78abae0f41558 rdf:first sg:person.013764547412.16
119 rdf:rest N2046423ff26847a795fb1b3753163d40
120 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
121 schema:name Biological Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
124 schema:name Genetics
125 rdf:type schema:DefinedTerm
126 sg:person.01125345436.28 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
127 schema:familyName Galili
128 schema:givenName N.
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125345436.28
130 rdf:type schema:Person
131 sg:person.013764547412.16 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
132 schema:familyName Cleary
133 schema:givenName M. L.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013764547412.16
135 rdf:type schema:Person
136 sg:person.0621216003.23 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
137 schema:familyName Sklar
138 schema:givenName J.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621216003.23
140 rdf:type schema:Person
141 sg:pub.10.1007/bf01534738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017412972
142 https://doi.org/10.1007/bf01534738
143 rdf:type schema:CreativeWork
144 https://app.dimensions.ai/details/publication/pub.1081364954 schema:CreativeWork
145 https://doi.org/10.1016/0378-1119(83)90040-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006623788
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/s0092-8674(85)80070-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001046047
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1056/nejm198211113072002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036959456
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1073/pnas.74.12.5463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025360556
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1073/pnas.82.21.7439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047611732
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1126/science.3929382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062622560
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1126/science.6093263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062634110
158 rdf:type schema:CreativeWork
159 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
160 schema:name Laboratory of Experimental Oncology, Department of Pathology, Stanford University, Stanford, California 94305, USA
161 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...