Ontology type: schema:Chapter
1998
AUTHORS ABSTRACTThe family of integrins comprise more than 20 αβ(3 heterodimeric membrane bound glycoproteins that mediate cell-cell and cell-extracellular matrix contacts. To date, 16 α and eight β subunits assemble noncovalently in a variety of combinations. In most instances, α chains associate with only one β chain while β chains are promiscuous. However, the α4 and αv subunits both associate with more than one β chain. Subfamilies of integrins are named according to the β chain used. The largest subfamily comprises the βi-integrins consisting of at least nine members. The integrins function as adhesion molecules as well as signal transducers by binding to a number of ligands (Clark and Brugge 1995; Zimmermann et al. 1996). Such ligands are either extracellular matrix proteins like fibronectin, laminin and vitronectin or members of the Ig superfamily like the intercellular adhesion molecules (ICAMs), the vascular cell adhesion molecule (VCAM-1) and the mucosal addressin cell adhesion molecule (MAdCAM-1). More... »
PAGES23-32
Leukocyte Integrins in the Immune System and Malignant Disease
ISBN
978-3-642-71989-9
978-3-642-71987-5
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