Treatment of Centroblastic-Centrocytic and Centrocytic Lymphomas at Advanced Stages — Results of the German Low-Grade Lymphoma Study Group View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

W. Hiddemann , M. Unterhalt , R. Herrmann , M. Tiemann , R. Parwaresch , H. Stein , L. Trümper , M. Nahler , M. Reuss-Borst , C. Tirier , A. Neubauer , M. Freund , E.-D. Kreuser , H. Dietzfelbinger , H. Bodenstein , A. Engert , R. Stauder , H. Eimermacher , K. Landys

ABSTRACT

The current multicenter study was initiated to address two major questions in the treatment of advanced stage non-Hodgkin lymphomas (NHL): (1) the activity of two different cytoreductive regimens and (2) the impact of interferon-α (IFN-α) maintenance. Patients with advanced stage III and IV centroblastic-centrocytic (CB-CC) and centrocytic (CC) lymphomas were randomized to initial therapy with either prednimustine/ mitoxantrone (PmM) or cyclophosphamide/vincristine/prednisone (COP). Responding cases underwent a second randomization for IFN-α or observation only. From the 525 evaluable patients 85% achieved a remission with similar overall response rates for PmM (85%) and COP (86%). Significantly more CR were obtained after PmM (35% versus 21% p IFN-α versus observation. As of November 1996 a significant advantage in favor of IFN-α was observed. In the IFN-α group the median DFS was 32 months as compared to 19 months in the control group (p = 0.0033). Analysis of IFN-α in association with initial cytoreductive treatment showed a more beneficial outcome for PmM plus IFN-α with an estimated median DFS of 43 months as compared to 27 months for COP plus IFNa. These data indicate a significant prolongation of DFS by IFN-α maintenance and suggest that this effect is related to the efficacy of initial cytoreductive chemotherapy. More... »

PAGES

1163-1168

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-642-71960-8_163

DOI

http://dx.doi.org/10.1007/978-3-642-71960-8_163

DIMENSIONS

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